Catheterization Lab Equipment in Ohio

Norman Noble is a Class III medical device contract manufacturer specializing in vascular and orthopedic implants. With 80 years of manufacturing experience, the company serves as a single-source solution for complex nitinol implant design and production, including vascular stents, heart valve components, heart pump devices, and neurovascular systems. For orthopedic applications, Norman Noble manufactures extremity screws, bone plates, and spine cages using precision 5-axis micro milling and turning capabilities. The company offers comprehensive services spanning design through high-volume production, with particular expertise in rapid prototyping and advanced manufacturing technologies. Core technological capabilities include proprietary Stealth athermal laser machining (HAZ-free processing), dry electropolishing, and Synchro Flash Swiss turning combined with laser machining. As the world's largest laser contract manufacturer of nitinol implants, Norman Noble develops custom manufacturing solutions for novel product designs. The company maintains state-of-the-art facilities with advanced EDM and laser processing equipment. Manufacturing services address device developers and OEMs requiring expertise in material science (particularly shape-memory alloys), precision machining, and regulatory pathway support for FDA-cleared and Class III medical devices. Norman Noble operates as a 24/7 manufacturing facility with demonstrated capability in both prototype development and commercial-scale production runs.

S4 Medical Corp is a Cleveland-based medical device company founded in 2017 specializing in safer catheter ablation treatments for atrial fibrillation (AF). The company's flagship product, esolution®, is the first and only FDA-cleared device designed to protect the esophagus during ablation procedures by using vacuum suction to deviate the esophagus away from the ablation catheter. This bilateral deviation capability accommodates individual patient anatomy and is compatible with any ablation energy source without requiring additional hardware or software integration. With approximately 33 million people worldwide living with AF and esophageal injury affecting up to 47% of ablation patients, esolution® addresses a critical clinical safety challenge. The device reduces thermal esophageal injury by 84%, decreases RF time by 18%, and minimizes temperature-related procedure interruptions by 9x. Designed by and for electrophysiologists, esolution® integrates seamlessly into existing catheter ablation workflows.

Nano4Imaging GmbH is a medtech company specializing in interventional MRI (iMRI) solutions that transform MRI from a purely diagnostic tool into a fully capable interventional platform. The company develops the trackr. technology ecosystem, which comprises three integrated components: EmeryGlide (an FDA-cleared, MRI-conditional, metal-free guidewire with nanoparticle coating for real-time visualization across all imaging modalities); Magnafy (an advanced multimodal nanoparticle composite applicable to any device for discrete marker visualization in MRI and CT); and trackr.ai (a proprietary deep learning algorithm that provides real-time, radiation-free catheter navigation with GPS-like tracking capability). The platform enables physicians to perform safe, precise interventions without ionizing radiation or nephrotoxic contrast agents, supporting diagnostic and therapeutic procedures in cardiology, particularly right and left heart catheterization and congenital heart disease management. Clinical evidence documents over 200 patients treated with zero procedural complications. The company has demonstrated 250 successful right heart catheterizations for pulmonary pressure assessment. Nano4Imaging collaborates with leading healthcare institutions across Europe and North America. The company was recognized among the top 3% European innovators by the European Innovation Council and received an Accelerator Grant for breakthrough technology potential. EmeryGlide is the world's first FDA-cleared MRI-compatible guidewire and is labeled MR conditional per ASTM standards F2182, F2052, F2053, and F2213. The company continuously expands its portfolio with MRI-compatible catheters and accessory tools.

Centerline Biomedical develops intraoperative navigation technology for endovascular and interventional procedures. The company's flagship product, IOPS® (Intra-Operative Positioning System), is a 510(k)-cleared navigation platform that provides real-time 3D color image guidance as an alternative to conventional X-ray fluoroscopy. IOPS® is designed to mitigate occupational and patient radiation exposure in interventional cardiology, vascular surgery, and complex endovascular procedures. The system offers interactive navigation, high-quality 3D imaging, and portability compared to traditional 2D fluoroscopy-based guidance. Clinical evidence presented on the site documents significant occupational hazards associated with fluoroscopy exposure, including radiation-induced cataracts, brain tumors, and orthopedic issues among interventionalists. IOPS® targets procedures estimated at 4 million annually in the United States. The company collaborates with major medical institutions including Cleveland Clinic, the U.S. Air Force 59th Medical Wing, and the U.S. Army Institute of Surgical Research, indicating validation in both civilian and military surgical settings. The technology is positioned for vascular surgeons, interventional cardiologists, and trauma surgeons performing endovascular therapy, aortic procedures, and complex case management where radiation dose is a clinical and occupational concern.

KAPP Surgical Instrument, Inc. is a leading manufacturer of custom-designed stainless steel surgical instruments and implants based in Cleveland, Ohio. As a full-service surgical design and supply firm, the company specializes in designing, prototyping, manufacturing, marketing, and distributing innovative surgical products in collaboration with renowned surgeons worldwide. KAPP manufactures the original Cosgrove® Valve Retractor System, considered the gold standard for cardiac valve surgery, along with extensive lines of specialized retractors for cardiovascular, orthopedic, ENT, colorectal, and vascular procedures. The company also produces custom orthopedic implants including radial head prostheses and anatomy-specific fixation systems, vascular clamps, surgical markers, and specialized instruments for general surgery and minimally invasive procedures. KAPP provides full instrument repair and refurbishing services for original products and most surgical instruments. The company maintains ISO 13485:2016 certification for quality management and serves a global customer base through direct sales and international distributors.

Vein360 specializes in FDA-cleared reprocessed radiofrequency ablation (RFA) and intravascular ultrasound (IVUS) catheters for vein centers. The company delivers cost-effective alternatives to original manufacturer catheters through a validated, environmentally sustainable reprocessing model. Leadership combines surgical expertise, biomedical engineering, and single-use device reprocessing knowledge. All IVUS catheters undergo rigorous multi-point visual inspections and electro-mechanical testing to ensure performance equivalent to new devices. Vein360 helps vein practices significantly reduce procedure costs and medical waste while maintaining clinical safety and device reliability.