S4 Medical Corp

S4 Medical Corp is a Cleveland-based medical device company founded in 2017 specializing in safer catheter ablation treatments for atrial fibrillation (AF). The company's flagship product, esolution®, is the first and only FDA-cleared device designed to protect the esophagus during ablation procedures by using vacuum suction to deviate the esophagus away from the ablation catheter. This bilateral deviation capability accommodates individual patient anatomy and is compatible with any ablation energy source without requiring additional hardware or software integration. With approximately 33 million people worldwide living with AF and esophageal injury affecting up to 47% of ablation patients, esolution® addresses a critical clinical safety challenge. The device reduces thermal esophageal injury by 84%, decreases RF time by 18%, and minimizes temperature-related procedure interruptions by 9x. Designed by and for electrophysiologists, esolution® integrates seamlessly into existing catheter ablation workflows.