Surgical Navigation Systems

Stryker Corporation is a global medical technology company headquartered in Portage, Michigan, serving hospitals, surgical centers, and healthcare providers worldwide. The company manufactures and distributes a comprehensive portfolio of medical devices, surgical equipment, implants, and visualization systems across multiple specialties including orthopedics, neurosurgery, spine, trauma, cardiovascular, endoscopy, acute care, and emergency medicine. Key product categories include joint replacement implants (hips, knees) with Mako Robotic-Arm Assisted Technology, neurosurgical and spine instruments with 3D-printed technologies, minimally invasive surgical systems (laparoscopy, arthroscopy, endoscopy), emergency care equipment, communications systems for patient environments, interventional spine products (vertebroplasty, radiofrequency ablation), craniomaxillofacial solutions, sports medicine implants, and neurovascular stroke care devices. Stryker operates manufacturing facilities in multiple countries including Canada, China, and the US. The company maintains a strong commitment to sustainability through device reprocessing and remanufacturing services for single-use medical devices. With regional headquarters and distribution centers across the Americas, Europe, Asia-Pacific, and Middle East & Africa, Stryker provides integrated sales, service, and technical support. The company is regulated by the FDA and maintains global certifications for medical device manufacturing and quality management systems.

Actuated Medical develops patented platform technologies for minimally-invasive brain access, implant insertion, and therapeutic delivery. The company specializes in two primary product lines: the NeuralGlider Inserter, which uses micro-oscillation technology to insert brain implants with improved precision and reduced tissue trauma, enhancing implant performance and longevity; and the NeuralGlider Injector, which enables targeted drug delivery deep into the brain using finer, less-invasive needles to minimize tissue damage and medication loss. These technologies serve partners developing deep brain stimulation (DBS), neurological implants, and intracranial drug therapies for conditions including Parkinson's disease, epilepsy, treatment-resistant neurological disorders, brain cancer, AAV gene therapy, and addiction treatments. Actuated Medical positions itself as a foundational platform provider that collaborates with leading innovators in neurotechnology and brain therapeutics. The company has demonstrated significant scientific traction through peer-reviewed publications and preclinical validation studies. Their technology addresses critical clinical needs in neurological treatment where precise brain access and minimal tissue trauma directly impact patient outcomes and long-term implant efficacy.

HJY Smart Medical Device Co., Ltd. (HJY Forward Medical Investment) is a Taiwan-based medical device manufacturer specializing in minimally invasive endoscopic surgery solutions and AI-assisted surgical technologies. Established in 2019, the company develops and manufactures innovative endoscopic vision systems addressing unmet needs in neuro- and orthopedic surgery. HJY's product portfolio includes FDA-approved VisualNext® 2D endoscopic vision systems for diagnostic and surgical applications, next-generation 3D head-mounted display (HMD) technology for real-time surgical visualization, and the HJY-YESS posterior lumbar retractor system for spine surgery. The company operates subsidiaries across China and the USA, positioning itself as a leader in next-generation endoscopy medtech with a focus on AI-integrated surgical platforms. HJY combines hardware innovation with artificial intelligence to advance minimally invasive surgical techniques.

Medtronic is a global healthcare technology leader serving 79+ million patients across diagnostic imaging, surgical and operating room equipment, intensive care, specialty medical, and homecare sectors. The company manufactures and distributes a comprehensive portfolio spanning cardiac rhythm and diagnostics systems, pacemakers, implantable cardioverter-defibrillators, deep brain stimulation devices, robotic surgery platforms, ventilators, anesthesia machines, infusion pumps, continuous glucose monitoring systems, insulin pumps, endoscopic and surgical navigation systems, and wound closure products. Recent FDA clearances include the Stealth AXiS surgical system for spine surgery and pulsed field ablation (PFA) technologies for atrial fibrillation treatment. Medtronic serves hospitals, surgical centers, critical care units, interventional labs, and home care settings through product lines in cardiac, vascular, neuromodulation, minimally invasive surgery, respiratory, and diabetes management. The company conducts 170+ active clinical trials, invests $2.7B annually in R&D, and holds FDA 510(k) clearances, CE marks, and ISO 13485 certification. Manufacturing and distribution capabilities span North America, Europe, and international markets with customer support available 24/7.

Computational Diagnostics, Inc. (CDI) is a manufacturer of clinical neurophysiology systems and provider of intraoperative neurophysiological monitoring (IOM/IONM) services. Founded in 1988, CDI develops and operates multi-modality neurophysiologic monitoring equipment designed to protect neural structures during surgical procedures. The company's flagship NeuroNet® platform enables real-time neurophysiological data acquisition and remote interpretation by attending neurophysiologists, allowing surgeons to monitor nervous system integrity during complex procedures. CDI offers turnkey IOM services with nationally certified neurotechnologists and neurophysiologists collaborating to deliver immediate clinical feedback. The company also develops telemedicine and home-use neurophysiology systems, supported by research funding from the Army's Telemedicine and Advanced Technology Research Center and the National Institute of Neurological Diseases and Stroke. CDI's technology has received recognition including Computer World/Smithsonian awards.

inTRAvent Medical Partners LP is a medical device company specializing in intra-operative imaging and neuro-navigation systems for neurosurgical procedures. The company develops portable ultrasound-based navigation technology enhanced with artificial intelligence and trajectory guidance to improve safety and efficacy in neurosurgery. Their flagship product, SOLOPASS®, combines 2D and 3D ultrasound imaging with AI-driven guidance to provide real-time procedural localization and navigation at the bedside. Designed for neurosurgeons performing minimally invasive procedures, the technology enables enhanced visualization of anatomical structures and catheter placement guidance. The company is focused on translating advanced imaging and navigation capabilities into practical, user-friendly solutions for intraoperative use.

Xironetic is a healthcare technology company specializing in augmented reality (AR) and mixed reality solutions for surgical applications. The company's flagship product, IntraOpVSP™, is an FDA-cleared augmented reality visualization software that transforms patient imaging data into three-dimensional holograms displayed in AR headsets during surgery. This enables surgeons to visualize surgical plans and anatomical targets in real-time across general, neuro, orthopedic, and vascular surgical disciplines. IntraOpVSP integrates CT and MRI imaging data with intuitive voice commands and gesture-based interfaces, providing hands-up reference displays that enhance surgical precision and decision-making. The company collaborates with clinical institutions, including the David Grant Medical Center, for product development and validation in complex surgical trauma cases.

Augmedit is a medical software company specializing in augmented reality (AR) technology for surgical procedures, medical education, and patient engagement. The company transforms 2D medical imaging data (CT and MRI scans) into interactive 3D holographic models, primarily compatible with Microsoft HoloLens 2. Augmedit's platform enables surgeons and clinical teams to conduct pre-operative planning, intra-operative guidance, and patient education using patient-specific holograms. The core product portfolio includes Lumi (cloud-based DICOM-to-3D conversion for 3D labs and researchers), LumiNE Lite (neurosurgical planning with automatic anatomical segmentation), and LumiNE Elite (intra-operative visualization with precise hologram-to-patient registration). Applications span neurosurgery, cranio-maxillofacial surgery, and emerging use cases in other surgical specialties. The subscription-based software integrates seamlessly into clinical workflows, supporting improved surgical outcomes, cost savings, and enhanced patient-clinician communication. Future developments include web and mobile platform compatibility.

MedCAD is a Dallas-based medical technology company founded in 2007, specializing in patient-matched surgical devices and virtual surgical planning solutions. The company leverages advanced 3D imaging, CAD software, and precision manufacturing to design customized implants, surgical guides, and anatomical models for complex reconstructive and corrective procedures. Core offerings include the AccuPlan® Surgical Planning System for virtual surgical design, AccuPlate® 3D-printed titanium reconstruction plates, AccuShape® cranial implants in PEEK or titanium, AccuModel® anatomical models for surgical visualization, and AccuStride® foot and ankle surgical solutions. MedCAD serves cranial, maxillofacial, orthognathic, oral, plastic, and orthopedic surgery specialties. The company manufactures in-house in Texas with FDA clearance for its surgical products. MedCAD's approach combines engineer and design expertise—including trained sculptors and product designers—to create precision instruments and implants tuned to individual patient anatomy, enabling surgeons to plan procedures virtually, reduce operative time, and improve clinical outcomes.

UNIVET is an Italian manufacturer specializing in the design and production of surgical loupes and magnification systems for dentistry, surgery, and medical applications, alongside premium dental safety eyewear and protective equipment. Founded in 1997, the company operates from a 3,000+ m² facility in Brescia, Italy, with 50+ employees and distribution across 40+ countries. UNIVET offers tailor-made and ready-made magnification loupes with variable Galilean optics (2.5x–6.0x magnification), integrated LED headlight systems (EOS wireless and wired variants), and specialized dental protective eyewear (anti-fog, anti-reflective coatings, face shields). The company is recognized for ergonomic design, Italian craftsmanship, light-weight construction using advanced materials, and rigorous quality control. Products serve dental practitioners, surgeons, and specialists requiring precision magnification and illumination for enhanced visibility and accuracy during clinical procedures.

Anschel Technology Inc. manufactures the SightSaver™, an FDA-approved and patented device for eliciting visual evoked potentials (VEPs) during intraoperative monitoring. The device is designed to prevent post-operative visual loss (POVL)—a serious complication affecting several thousand patients annually in the United States following non-ocular surgical procedures such as spine surgery. The SightSaver™ addresses critical gaps in existing visual stimulation approaches by providing a hygienic, safe, comfortable, and reliable alternative to low-quality, non-hygienic, and unreliable legacy stimulators. The company was founded in 2011 by Dr. David Anschel, a board-certified neurologist and clinical neurophysiologist with extensive academic credentials and research background. The SightSaver products enable perioperative vision risk management through real-time intraoperative visual monitoring, supporting surgical teams in detecting and mitigating vision loss during high-risk procedures.

Lumicell, Inc. is a medical technology company founded in 2009 as a spinout from MIT that specializes in fluorescence-guided imaging systems for intraoperative tumor detection and resection. The company's core platform, LumiSystem, combines LUMISIGHT (a fluorescent optical contrast agent) with the Lumicell Direct Visualization System (DVS), a handheld real-time imaging device for surgical guidance. In April 2024, both LUMISIGHT and DVS received FDA approval as the first drug-device combination approved in over a decade for this indication. The technology is designed to help surgeons identify and remove residual cancer tissue while preserving healthy tissue during breast cancer lumpectomies and other oncologic procedures. Lumicell has validated its approach in clinical studies involving over 700 breast cancer patients and is expanding applications to solid tumors including gastric and gastrointestinal cancers.

Image Navigation Ltd. manufactures the FDA-approved Image Guided Implantology (IGI) system, a high-precision surgical navigation platform for dental implantology and other precision surgeries. The IGI 2.0 Hybrid Surgical Navigation and Robotics System integrates real-time 3D guidance with robotic safety features, enabling dentists to perform implant procedures with enhanced accuracy, reduced trauma, and improved patient outcomes. The system leverages in-office dental CT scans for comprehensive planning and execution, featuring proprietary technologies including TRAX real-time tracking (0.35 mm ±0.14 mm accuracy with 20 ms refresh rate), intelligent drill with Spatial Awareness, robotic autostop for safety, and MiniLOCK patient-tracker connection for sustained accuracy. The platform streamlines workflow, reduces chair time, and accommodates dentists at all skill levels, supporting same-day treatment protocols and practice growth through increased case acceptance and predictable outcomes.

InnoVital LLC is a Beltsville, Maryland-based advanced technology company with dual operating divisions: InnoVital Defense and InnoVital Health. The company develops innovative medical device solutions and specialized equipment addressing critical clinical and emergency care needs. InnoVital's multidisciplinary team of physicians, engineers, and entrepreneurs designs and manufactures novel medical devices including surgical airway guidance systems, pleural access anatomical guides, rapid casualty extraction and patient transport systems, catheter-based suction-irrigation devices, and respiratory therapy accessories. The company leverages core competencies in advanced electronics, sensors, actuation, signal processing, and control systems to create purpose-built solutions for emergency medicine, surgical interventions, and home respiratory care. InnoVital maintains strong relationships with the US Defense Health Agency and clinical institutions, with active clinical trials and continued government funding supporting product development and commercialization.

Point Robotics MedTech Inc. is a leading developer of surgical navigation systems and robotic-assisted surgery platforms designed to advance minimally invasive orthopedic and neurological procedures. The company specializes in assistive surgical robotics with integrated navigation technologies that enhance surgical precision, safety, and reliability in the operating room. Point Robotics' flagship offering, the Kinguide Agile Robotic Arm Surgical Stereotactic System (Taiwan TFDA-approved), combines real-time trajectory guidance, optical tracking, and broad 3D imaging compatibility to reduce surgical variability and improve patient outcomes. The company emphasizes clinically proven minimally invasive solutions for spinal surgery and related orthopedic applications, with commitment to innovation in robotic-assisted surgical technologies that deliver measurable clinical benefits to physicians and healthcare institutions.

Dupaco Inc is an FDA-registered, ISO 13485-certified medical device manufacturer specializing in patient safety solutions for perioperative environments. The company designs and manufactures innovative surgical positioning devices, prone positioning systems, and eye protection solutions for operating room and anesthesia settings. Dupaco's product portfolio includes the ProneView System for safe prone positioning during surgery, Opti-Gard and Laser Opti-Gard eye protection barriers to prevent perioperative visual loss and corneal injury, and specialized patient protection devices. The company serves hospitals, surgical centers, and anesthesia providers, offering both proprietary medical devices and contract manufacturing capabilities. Dupaco is actively engaged with major clinical associations including the American Society of Anesthesiologists (ASA) and the New York Society of Anesthesiologists (NYSSA).

Neuralytix develops proprietary mechanomyography (MMG) technology for intraoperative nerve assessment during spinal surgery. The FDA-cleared iD3 System provides surgeons with real-time, objective measurements of nerve function through non-invasive accelerometer sensors, replacing subjective tactile feedback and invasive EMG. The system assists in nerve locating, mapping, and decompression assessment across minimally invasive and open spinal procedures, including fusion, discectomy, laminectomy, and foraminotomy. MMG enables surgeons to quantify neural response threshold changes throughout surgery, improving decision-making precision and reducing reoperation risk while eliminating procedural complexity associated with traditional EMG monitoring.

SmartSurgN Inc. is a Silicon Valley-based medical technology company specializing in advanced surgical visualization systems and fluid management devices. The company manufactures the SmartSurgN 4K ICG Visualization System, a high-resolution surgical imaging platform offering four imaging modalities (one visible mode and three fluorescence overlays) for precise visualization of vessels, blood flow, and tissue perfusion during minimally invasive procedures. Additionally, SmartSurgN produces the AirSurgN™ 50L Insufflator, a compact and lightweight gas management device with integrated smoke evacuation for enhanced operative clarity during electrosurgery. The company also designs custom rigid endoscopic scopes optimized for infrared imaging compatibility and system integration. Built on expertise in photonics, mechanronics, and embedded software, SmartSurgN's products are engineered to simplify complex surgical workflows through intuitive controls, seamless integration, and uncompromising image quality. The company has achieved FDA Pre-Market Clearance and ISO certification.

OnPoint Surgical is a medical technology company specializing in augmented reality (AR) and artificial intelligence (AI) guidance for spinal surgery. The company's flagship product, the OnPoint AR Spine System, received FDA 510(k) clearance in September 2023. The system uses a lightweight head-mounted display (under 4 ounces, 4K resolution) to project virtual surgical guides and 3D anatomical landmarks directly onto the surgeon's visual field during procedures. Key capabilities include real-time surgical planning, virtual implant visualization, and intraoperative decision support for pedicle and cortical screw placement, lumbar interbody cage positioning, and cervical spine procedures. The platform is vendor-agnostic, compatible with implants and instruments from all major manufacturers, and integrates seamlessly into existing surgical workflows without requiring technique modifications. OnPoint AR preserves tactile feedback—a critical advantage over robotic systems—while reducing setup time to under 5 minutes and potentially decreasing OR time by approximately 20 minutes through pre-operative CT planning.

PathKeeper Surgical is an Israeli medical technology company specializing in advanced 3D optical navigation systems for precision spine surgery. The PathKeeper™ Full Spine Navigation System is an FDA-cleared device that utilizes proprietary ultra-high-resolution 3D optical technology and artificial intelligence to provide real-time, radiation-free surgical guidance. The system features independent active tracking for continuous anatomical updates, AI-enabled preoperative planning, and a compact, mobile design suitable for hospital operating rooms and ambulatory surgical centers. The platform reduces surgical failure rates, eliminates intraoperative radiation exposure, and simplifies complex spine procedures through intuitive workflow optimization. PathKeeper's technology is implant-agnostic and designed to enhance surgical precision while improving clinical outcomes and economic value for healthcare providers.

TrackX Technology is a medical device manufacturer specializing in universal instrument tracking technology for surgical applications, particularly orthopedic and trauma procedures. The company's core product, TrackX, provides real-time virtual live fluoroscopy during surgery using disposable tracking components (TrackX Snap) that attach to surgical instruments and implants. The system recalibrates with each new x-ray, eliminating the need for bulky equipment or capital purchases. Key clinical benefits include significant radiation dose reduction (91.8% reduction in radiation exposure), substantial reduction in x-ray frequency (74.8% fewer x-rays required), and meaningful OR time savings (average 56-minute reduction per procedure). The three-step setup process—apply Snap, take x-ray, track in real-time—simplifies adoption and reduces sterilization burdens. Designed for surgeons, hospital executives, and surgical teams seeking efficiency and safety improvements in minimally invasive and open surgical procedures.

Loocid LLC is a Miami-based medical device innovator specializing in computer-assisted surgical solutions for dental implant and bone surgery procedures. The company designs and manufactures specialized drill kits with thermal control technology (Loocid BCP™ system) that minimize bone cell trauma and preserve healthy bone during osteotomy preparation. Their product line includes custom and universal implant drill kits engineered to reduce thermal trauma during bone drilling, support osseointegration, and accelerate patient healing. Loocid combines mechanical drilling innovations with 3D imaging technology and AI-driven digital workflows to enable minimally traumatic surgical techniques. The company targets dental surgeons, oral and maxillofacial surgeons, and orthopedic professionals seeking clinically-proven tools that improve patient outcomes and reduce post-operative complications.

Surgical Planning Associates (SPA) is a Boston-based medical technology company specializing in surgical navigation and preoperative planning solutions for orthopedic procedures. The company's flagship product, the HipInsight System, is the world's first FDA-cleared mixed reality navigation platform designed specifically for total hip arthroplasty. The system utilizes Microsoft HoloLens 2 mixed reality glasses to provide surgeons with real-time 3D holographic overlays of patient-specific anatomy, surgical instruments, and preoperative plans, effectively giving surgeons "x-ray vision" during surgery. HipInsight combines cloud-based preoperative planning with intraoperative guidance, achieving accuracy within 3 degrees of target anteversion and inclination. The platform integrates seamlessly into existing surgical workflows and can be deployed in under 5 minutes in the operating room. With over 11,000 hip replacement surgeries performed using SPA's technology across four continents, the company has established itself as a leader in digital surgery solutions. SPA maintains a co-marketing partnership with Zimmer Biomet and serves hospital systems and surgical centers seeking to improve implant positioning precision and surgical outcomes.

Brain Navi is a Taiwan-based neurosurgical medical device company specializing in advanced surgical navigation and visualization systems for intracranial procedures. The company manufactures two primary product lines: NaoTrac, an autonomous neurosurgical navigation robot that guides surgeons to target locations following pre-planned surgical pathways, and KrystoLens, a single-use 2D/3D neuro-endoscope with a wide surgical working channel designed for minimally invasive intracranial surgery. NaoTrac achieved FDA clearance in June 2025 and has been deployed at leading neurosurgical centers including Medizinische Universität Lausitz in Germany. The company's mission is to improve surgical accuracy, streamline neurosurgical procedures, and reduce surgeon learning curves. Products are designed for neurosurgeons performing brain and spinal procedures requiring high precision and visualization. Brain Navi serves international markets and participates in major medical conferences and surgical events to demonstrate clinical applications and train surgical teams.

FHC, Inc. is a specialized medical device manufacturer based in Bowdoin, Maine, founded in 1970. The company focuses on neuroscience and neurosurgery solutions, particularly cranial microtargeting and neuromodulation. FHC designs and manufactures microelectrodes, electrode positioning systems, stereotactic platforms, and surgical planning software for both clinical and research applications. Their clinical product line includes the Guideline 5 Neuromodulation System, STarFix Stereotactic Platforms, STar Microdrive System, and WayPoint Navigation software for surgical planning. The research division offers NeuroCraft microelectrodes and insertion tubes for neurophysiology studies. FHC's solutions support therapeutic interventions including deep brain stimulation, ablation, resection, and treatment of movement disorders such as Parkinson's Disease, epilepsy, dystonia, and essential tremor. The company also provides stereoelectroencephalography (SEEG) equipment and operates Greenville Neuromodulation Services for DBS research and surgeon training. With approximately 170 employees and estimated annual revenue of $42.6 million, FHC serves neurosurgical centers and research institutions globally.

Ruthless Spine manufactures the RJB™, an intraoperative surgical angle measurement tool designed for lumbosacral pedicle screw placement procedures. The RJB system measures axial and sagittal angles of surgical instruments relative to gravity in real-time, providing surgeons with precise angle tracking during spinal surgery. The device connects via Bluetooth to standard tablets (Android OS 10+ or iOS 14+) and displays real-time visualization of instrument trajectory in two planes. The RJB offers a cost-effective alternative to traditional surgical navigation systems, eliminating the need for expensive, bulky imaging equipment while maintaining ease of use with minimal training requirements and simple 30-second setup. Each single-use RJB module provides up to 8 hours of continuous operational use. The device is FDA-cleared (De Novo clearance DEN230012) as a measurement tool and does not provide surgical guidance, navigation, or assistance against patient anatomy. Ruthless Spine positions the RJB as an elegant, efficient solution addressing the barriers—cost, complexity, and learning curve—associated with conventional surgical navigation for spine procedures.

Gyder Surgical US Inc manufactures the GYDER® Hip System, a patented pin-less surgical navigation platform designed for anterior hip replacement procedures. The system enables image-free, pin-less navigation without requiring CT or X-ray imaging, reducing radiation exposure and procedural complexity. The GYDER® Hip System features a non-invasive approach with no fixative fixation points, simple setup with rapid calibration, and seamless integration into existing OR workflows. The platform operates as an open system compatible with surgeon-preferred implant systems, supporting both traditional OR and ambulatory surgery center (ASC) environments. Designed for portability with minimal medical waste generation, the system facilitates precise surgical placement while reducing operative time and patient burden. Currently available for distribution in the United States and Australia, the GYDER® Hip System targets orthopedic surgeons and surgical facilities performing hip arthroplasty procedures. The company markets directly to physicians and through distributor channels.

Novarad Corp is a medical software and digital imaging solutions company headquartered in Provo, Utah, with over 30 years of innovation in enterprise medical imaging. The company specializes in PACS (Picture Archiving and Communication Systems), enterprise imaging, and augmented reality surgical navigation. Novarad's product portfolio serves hospitals ranging from 26 to 500+ bed facilities, critical access hospitals, rural hospitals, imaging centers, and clinics. Core offerings include NovaPACS with Enterprise Imaging (customizable PACS platform with HL7 integration capabilities), VisAR (FDA-approved fully immersive 3D augmented reality surgical navigation system for spine and cranial neurosurgery), MobileRad 360 (mobile EMR ecosystem), Nova RIS (radiology information system), CryptoChart (medical image sharing), NovaCardio (cardiology solutions), and MammoIQ (mammography software). The company supports cloud, on-premises, edge, and hybrid deployment models. Novarad maintains strategic partnerships with major healthcare IT vendors including eClinicalWorks, NextGen, Medent, and others. The company is known for USA-based 24/7 customer support and implementation services. VisAR has received FDA clearance for precision spine surgery and regulatory approval in Indonesia for stereotactic spine surgery. The company demonstrates expertise in enterprise imaging interoperability, workflow optimization, and specialized imaging across radiology, cardiology, and mammography.

RG Medical USA manufactures endoscopic instrumentation and robotic surgical navigation systems for minimally invasive urology and ENT procedures. Core product portfolio includes the Robotic Navigation Genius—a multifunctional robotic platform compatible with endoscopes, instruments, microscopes, and navigation systems for precision-guided surgical applications. The company also produces endoscopic instruments including the Morcescope Universal (available in 19/22, 22/24, and 24/26 Fr sizes) and the Duo Mono-Bipolar system for bipolar saline resection procedures (22/24 and 24/26 Fr). Products are designed for transurethral resection and other minimally invasive endoscopic procedures. RG Medical maintains multilingual customer support (English, Spanish, German) and operates from a US location with international distribution capabilities. The company positions itself in the premium surgical instrumentation and robotic navigation segment, serving hospitals and surgical centers performing advanced urological and endoscopic procedures.

Caira Surgical is a New York-based medical technology company founded in 2019, specializing in advanced software, scanning, and precision radar technologies for orthopedic joint replacement surgery. The company develops radar-based surgical tracking systems delivering sub-millimeter accuracy and navigation platforms designed to enhance surgical precision, reduce setup time, and improve patient outcomes. Caira's proprietary technology is protected by multiple U.S. patents (11,432,882, 11,351,007, 11,510,739, with additional patents pending). The company's first product is a navigation system for knee replacement utilizing fast anatomic landmark registration, with planned expansion to hip, shoulder, and spine procedures. Caira emphasizes reliability, intuitive adoption, efficiency (5x reduction in technology setup time), and affordability (10x cost improvement over conventional systems), making advanced navigated and robotic surgery accessible to diverse surgical settings.

ZETA Surgical Inc. designs and manufactures AI-powered frameless neuronavigation systems for cranial surgery and neuromodulation procedures. The company's core platform, REALTRACK™, delivers real-time image-guided navigation with submillimeter accuracy and live continuous surgical guidance tracking patient movement at 20 times per second. The system eliminates the need for cranial pin fixation and general anesthesia, enabling bedside procedures in operating rooms, emergency settings, and ambulatory surgical centers. Primary clinical applications include external ventricular drain (ventriculostomy) placement, brain biopsy, transcranial magnetic stimulation (TMS) targeting, and tumor resection such as cavernoma removal. Clinical data demonstrates 100% single-pass catheter placement success for ventriculostomy (versus 81% freehand), 100% ideal placement (versus 32% freehand), zero adverse events and revision surgeries. The TMS Navigation System achieved FDA 510(k) clearance in October 2025. ZETA's technology integrates AI-based image analysis, ultra-fast system setup, and real-time guided intervention. The company is backed by leading neurosurgeons and research institutions including Harvard Medical School, Brigham and Women's Hospital, and Imperial College London. ZETA serves hospital operating rooms, neurosurgical centers, and interventional procedure suites primarily in the United States.

NaviNetics Inc. is a medical device company founded by researchers, engineers, and neurosurgeons from the Neural Engineering Laboratories at Mayo Clinic in Rochester, Minnesota. The company specializes in stereotactic neurosurgery systems for precise target localization and patient head fixation during minimally invasive procedures. Their flagship product is the NaviNetics Reusable Stereotactic System, a frame-based neurosurgical targeting platform designed for deep brain stimulation (DBS), lesioning, biopsies, targeted injections, aspirations, and minimally invasive tumor treatments. The system combines the accuracy and workflow efficiency of traditional frame-based systems with a compact, ergonomic design. Key features include skull anchor fixation (eliminating the need for a base frame), intuitive targeting adjustments, excellent burr hole access, and procedural sterile field integrity. The system is compatible with standard CT and MR imaging localizers, enabling planning workflows consistent with conventional DBS frame methodology. Optional adapters support integration with third-party microdrive systems (AO and FHC). The product is designed to improve patient experience, accelerate DBS workflow, and maintain the accuracy verification standards expected in neurosurgical applications. NaviNetics targets hospitals and surgical centers performing stereotactic neurosurgery, with particular focus on DBS programs and functional neurosurgery.

Radlink, Inc. is a medical device software company specializing in intraoperative imaging navigation and surgical guidance systems for orthopedic surgery, with primary focus on hip arthroplasty (total hip replacement). The company develops AI-powered software platforms that integrate with standard fluoroscopy (C-arm and mobile X-ray) systems to provide real-time, patient-specific surgical guidance without requiring specialized hardware or invasive tracking. Core products include Radlink One Touch (redesigned surgeon's checklist interface), Radlink Hip (anterior and posterior approach THA software), Radlink3D (3D intraoperative assessment of acetabular cup and femur positioning with spinopelvic mobility analysis), Panoramic Fluoro (panoramic fluoroscopic imaging), and OrthoPlan 2.0 (preoperative planning). The platform operates as an open system compatible with any implant brand and any C-arm or mobile X-ray device on the market. Software enhancements include spinopelvic assessment for functional component positioning and leg length discrepancy prediction. Radlink also offers DR Pro (digital radiology software) and PACS/EMR/Citrix integration capabilities. The company markets to surgeons, hospitals, and health systems seeking to improve OR efficiency, reduce costs, and enhance clinical accuracy. Headquarters: El Segundo, California. The technology is clinically validated with peer-reviewed publications in orthopedic journals and is actively promoted through industry conferences including AAHKS (American Association of Hip and Knee Surgeons).

Illuminant Surgical develops real-time surgical navigation systems using artificial intelligence, computer vision, and dynamic projection mapping to enhance image-guided procedures. The company's flagship product, Skylight™, is a non-invasive anatomical projection system designed for spine surgery and interventional access procedures. Skylight projects imaging directly onto the patient's anatomy, eliminating the cognitive burden of traditional navigation systems that require surgeons to mentally translate 2D scans into 3D spatial awareness while constantly shifting attention between screens and the surgical field. The system employs SkinMatch™ patient registration technology to streamline workflow integration into any procedure room with minimal training (one day) and setup time (minutes rather than 30+ minutes). Illuminant Surgical addresses a critical gap in surgical technology by making advanced navigation accessible beyond major medical centers—scaling the solution to ambulatory surgical centers, private specialty clinics, and pain management facilities. The company's technology reduces operational friction, decreases OR costs, and expands treatment capacity. As of the website content, Skylight has not received FDA clearance and is not available for commercial use. The company is led by co-founders listed in Forbes 30 Under 30 Healthcare and is advised by prominent clinical and engineering leaders from USC Spine Center, Stanford Biodesign, and Stanford Medical Mixed Reality Lab, as well as business advisors including the founder of Masimo and former Stryker executive.

Navigate Surgical Technologies develops the Inliant System, a dynamic surgical navigation platform for freehand dental implant procedures. The system uses real-time motion tracking of the clinician's handpiece and patient position, overlaying precise drill angulation and trajectory on CBCT scans displayed in real-time during surgery. The platform comprises three core components: an attachment-free dental handpiece (requiring no pre-surgical calibration), a patient tracker set affixed to a chairside-fabricated stent for maintaining registration with the CBCT scan, and an optimized cart with full-length arm and adjustable monitor designed for any operatory configuration. The system enables same-day implant planning and surgery, eliminates or reduces intraoperative radiographs, and allows adaptive surgical planning in real-time. Primary clinical applications include single and multiple implant placement in aesthetically challenging zones, areas with questionable bone volume, limited vertical space, diverging roots, or tight interdental spacing. The Inliant System has received FDA 510(k) clearance. Navigate targets oral and maxillofacial surgeons, periodontists, and general dentists performing implant procedures.

Globus Medical, Inc. is a musculoskeletal medical device company specializing in spine surgery, orthopedic implants, and enabling surgical technologies. The company develops procedurally integrated portfolios for minimally invasive and open spine procedures, including TLIF (Transforaminal Lumbar Interbody Fusion), XLIF (Lateral Lumbar Interbody Fusion), and expandable interbody spacers. Key technology platforms include Excelsius Technology (an ecosystem of advanced OR technologies), Advanced Materials Science featuring PEEK and titanium implants, and proprietary magnetically adjustable systems for limb reconstruction (Precice). The company manufactures cervical disc replacements (Simplify Cervical Disc), power instruments (Verzera and DuraPro), and surgical navigation systems designed to improve safety and clinical outcomes. Globus Medical serves spine surgeons, orthopedic surgeons, and hospital systems globally through a comprehensive portfolio addressing sagittal alignment, fusion, fixation, and patient anatomy protection. The company emphasizes procedural integration, clinical education, and surgeon training through its Medical Education & Research Center (MERC), offering multimodal learning pathways and continuing surgical education. Manufacturing capabilities include advanced materials processing and enabling technology integration. The organization operates with regulatory compliance across major markets and demonstrates commitment to improving quality of life for patients with musculoskeletal disorders through innovation and surgeon partnership.

Cision Vision is a medical technology company specializing in shortwave infrared (SWIR) imaging systems for pathology and surgical applications. Founded in 2020 as an MIT spinoff, the company's flagship InVision device provides label-free, real-time imaging that enhances lymph node identification and tissue grossing in laboratory and intraoperative settings. The technology leverages SWIR wavelengths (1000–2000 nm) to penetrate biological tissues deeply and provide natural contrast based on water and lipid content, eliminating the need for contrast agents or radiation. InVision has been recognized as one of Time Magazine's Best Inventions of 2023 and is deployed across multiple U.S. hospitals. The company's surgical application focuses on AI-powered critical structure identification during intraoperative guidance. Cision Vision has received significant government funding, including a prestigious ARPA-H award of up to $22.3 million as part of the Biden Cancer Moonshot initiative. The company collaborates with leading institutions including Johns Hopkins Medicine and Stanford Medicine, and operates the Visionary Program to support early-access initiatives for pathology innovators. Clinical validation includes a multicenter study published in the Journal of Clinical Pathology.

Ceevra is a medical software company that develops FDA-cleared machine learning and computer vision algorithms to generate detailed, interactive 3D digital models from CT and MRI imaging studies. The platform automatically processes imaging data without requiring manual input from hospital personnel and delivers 3D surgical visualization accessible on mobile devices, tablets, laptops, and integrated surgical robotic displays. Ceevra's 3D models are clinically validated to improve surgical planning and patient outcomes across multiple surgical specialties including thoracic, urologic, gynecologic, and general/hepatopancreaticobiliary (HPB) surgery. The solution supports open, laparoscopic, and robotic-assisted surgical approaches. Clinical evidence published in JAMA Network Open demonstrates significant improvements in surgical outcomes, including enhanced cancer control, functional preservation, and reduced adjuvant therapy rates in robotic urologic procedures. Ceevra serves major U.S. healthcare systems including UCLA Health, Mayo Clinic affiliates, Memorial Sloan Kettering, Baptist Health South Florida, and Tulane University School of Medicine. The company operates on a subscription model with implementation designed for rapid deployment across hospital networks.

ImmersiveTouch develops advanced surgical planning and visualization software leveraging virtual reality and augmented reality technology for trauma and reconstructive surgery. The company provides patient-specific imaging analysis and immersive 3D visualization platforms (ImmersiveView, ImmersiveAR) that enable surgeons to plan complex procedures with enhanced spatial understanding and accuracy. Their solutions are deployed across 100+ sites in 6+ surgical specialties including craniofacial and maxillofacial surgery, plastic and reconstructive surgery, orthopedics, neurosurgery, thoracic surgery, and general surgery. Over 3,000 surgical cases have been completed using ImmersiveTouch technology. Customers include major academic medical centers and trauma hospitals such as Mayo Clinic, Cleveland Clinic, MD Anderson, Shriners Hospitals for Children, Walter Reed, and University of Illinois Health. The platform integrates with patient imaging data to create manipulable 3D models viewable in VR headsets, reducing surgical time and improving preoperative planning accuracy. The company operates from Chicago, Illinois, and serves both hospital systems and private surgical practices.

Augmedics Ltd. manufactures xvision, an FDA-approved augmented reality surgical navigation system for spine surgery. The technology uses AR headset visualization to overlay 3D anatomical data directly into the surgeon's field of view during procedures, eliminating the need to look away from the patient to reference external monitors. xvision is indicated for open, minimally invasive, and percutaneous spine procedures from C3 through the pelvis, including single and multi-level degenerative, trauma, revision, and complex deformity cases. Clinical data demonstrates 97–100% accuracy in pedicle screw placement and has been deployed in over 12,000 patient treatments with 66,000+ screws navigated. The platform integrates preoperative or intraoperative registration, operates on an open architecture, and features an intuitive 3D interface with minimal learning curve. Augmedics positions the technology as reducing radiation exposure, improving surgical efficiency, shortening operative times, and enhancing patient outcomes while maintaining surgeon workflow and control. The company emphasizes broad procedural applicability, economic scalability, and reproducible outcomes supported by peer-reviewed clinical evidence.

Soteria Medical B.V. is a specialized medical device manufacturer focused on MRI-guided in-bore prostate biopsy solutions. The company has developed a proprietary Remote Controlled Manipulator (RCM)—a fully MRI-compatible robotic device for precision prostate interventions. The RCM enables real-time, near real-time targeting of suspicious prostate lesions within the MRI bore, significantly improving diagnostic accuracy for prostate cancer detection and reducing the need for multiple unnecessary biopsy cores. The RCM system addresses key clinical challenges: it delivers high diagnostic accuracy (reported 70% prostate cancer detection rates), reduces procedure duration (typically under 30 minutes), minimizes patient discomfort by eliminating general anesthesia, and improves specimen quality for pathological analysis. The device features intuitive planning software and remote needle-guide positioning, enabling radiologists to perform precise, guided biopsies with minimal patient motion and reduced in-bore time. Soteria Medical's technology has been validated by leading radiologists across multiple institutions in Europe (Spain, Italy, Netherlands, France, Norway), with testimonials emphasizing clinical safety, diagnostic efficiency, and positive patient experience compared to transrectal ultrasound (TRUS) guidance. The company's offering is positioned for hospital radiology departments and diagnostic imaging centers specializing in urologic oncology and prostate cancer diagnosis. Recent market recognition includes CMS introduction of dedicated CPT codes (55713, 55714) for in-bore MR-guided prostate biopsy, reflecting clinical differentiation and reimbursement support in the US market. Soteria Medical is an active participant in major medical imaging conferences (ECR).

Citieffe is an Italian orthopedic and trauma surgery medical device manufacturer headquartered in Calderara di Reno, Bologna. The company specializes in trauma and extremity solutions, limb reconstruction, and surgical navigation systems for orthopedic trauma surgeons. Their primary product portfolio centers on intramedullary nailing systems for fracture fixation, notably the EBA One Single Lag Screw nailing system, which has been expanded in the U.S. market with the introduction of the EBA One Medium nail. The company positions itself as delivering essential, versatile solutions combining creativity, technological innovation, and high-quality standards for traumatology and orthopedic reconstruction. Citieffe maintains an active presence at major orthopedic conferences including AAOS (American Academy of Orthopaedic Surgeons), SECOT (Spanish Society of Orthopedic Surgery), and the Trauma Meeting in Italy, indicating significant engagement with international orthopedic and trauma markets. The company distributes through international partners and maintains a dedicated U.S. market presence. Citieffe s.r.l. is registered with Italian business authorities (Codice Fiscale 00574250379, Partita Iva 00516271202) with significant capital base (€4.7 million). The company emphasizes surgeon-centric design principles: essential instrumentation, simplified and reproducible operative procedures, and versatile utilization across patient populations. Information and technical materials on the site are directed toward healthcare professionals.

MindTrace is a Pittsburgh-based AI/ML software platform (Carnegie Mellon University spinoff, founded 2020) designed to support neurosurgical planning and intraoperative decision-making. The platform integrates multiple data sources to enable clinicians to predict cognitive outcomes before, during, and after brain surgery. MindTrace provides structured neurocognitive assessment workflows—measuring language, memory, attention, and other critical functions—allowing surgical teams to iterate on resection strategies while evaluating trade-offs between lesion removal and preservation of healthy brain tissue. The system integrates into clinical, operating room, and epilepsy monitoring workflows, supporting inpatient, perioperative, intraoperative, and telehealth settings. Used across U.S. medical centers under IRB oversight, MindTrace bridges clinical neurocognitive assessment with translational research data collection, enabling reproducible multi-site studies without custom infrastructure. The platform serves neurosurgeons, hospitals, researchers, and patients seeking evidence-based preoperative surgical planning and quantitative projections of postoperative function and quality of life.

Mammotome is a global breast care company specializing in diagnostic and surgical solutions for breast cancer detection and treatment. The company manufactures vacuum-assisted breast biopsy systems, stereotactic biopsy devices, MR-guided biopsy platforms, and surgical marker navigation systems. Product portfolio includes the Mammotome PrimaTM MR System (in-room, vacuum-assisted MR breast biopsy), Mammotome RevolveTM and RevolveTM ST stereotactic biopsy systems, Mammotome DualCoreTM and Elite systems, Pintuition® surgical marker navigation system, Neoprobe® GDS gamma detection system, and comprehensive biopsy site markers (HydroMARKTM Plus, standard markers). The company serves 60 countries with 550+ associates across 9 global locations. Mammotome holds FDA clearances for its MR biopsy systems and markers, and Health Canada approval for the Pintuition® System. As a Danaher-owned company, Mammotome integrates advanced imaging compatibility and procedural efficiency into products designed for radiologists, surgeons, and pathologists in hospital and outpatient diagnostic centers.

MediView XR, Inc. is a clinical augmented reality med-tech company specializing in first-in-class AR-powered visualization and navigation solutions for image-guided surgical and interventional procedures. The company develops mixed-reality platforms that overlay real-time 3D anatomical data, live ultrasound imaging, and procedural guidance directly into the surgeon's field of view via holographic heads-up displays. MediView's flagship products—OmnifyXR® Interventional Suite and XR90™ Holographic Surgical Navigation System—enable minimally invasive, ultrasound-guided soft tissue and bone procedures with improved ergonomics, workflow efficiency, spatial visualization depth, and real-time collaborative remote consultation and proctoring capabilities. The XR90 is FDA 510(k)-cleared and integrates seamlessly with GE HealthCare's Allia interventional imaging platform. Primary markets include interventional radiology, minimally invasive surgery, orthopedic surgery, and urological procedures. The company partners with leading academic medical centers and hospitals including The Cleveland Clinic, Mayo Clinic, NewYork Presbyterian/Weill Cornell Medicine, Memorial Sloan Kettering, and Ohio State University. MediView is Microsoft Gold partner and member of the American Medical Extended Reality Association. Recent Series A funding of $24M was led by GE HealthCare, Mayo Clinic, and Cleveland Clinic.

Unik Orthopedics develops personalized medical devices and cloud-based surgical planning software for total knee and hip replacement procedures. The company provides an open-platform solution combining advanced imaging analysis, customized 3D surgical planning, personalized single-use surgical instruments, and robotic-assisted technologies that work with any implant brand. Using MRI or CT imaging, the company creates precise 3D anatomical models of each patient, enabling surgeons to develop individualized surgical plans optimized for implant size, alignment, and placement. Custom instruments are manufactured in their California facility and delivered within two weeks of imaging. The technology reduces surgical steps, requires fewer instruments, and improves procedural efficiency and consistency compared to conventional instrumentation. Unik Orthopedics partners with healthcare facilities, orthopedic surgeons, and implant manufacturers to enhance patient outcomes and surgical precision. The company positions its personalized approach as reducing error margins and improving patient satisfaction in joint replacement surgery.

Surgical Theater, Inc. develops eXperiential Reality (XR) platforms that transform 2D medical imaging (MRI, CT, DTI) into interactive 3D surgical models using AI-driven reconstruction technology. The company serves neurosurgery, spine surgery, and otolaryngology specialties with three primary solutions: PlanXR™ for preoperative surgical planning and rehearsal; Brain STORM™ for epilepsy care management; and SyncAR® (Spine and Cranial variants) for real-time intraoperative augmented reality visualization. Additional products include XR Studio™ for multidisciplinary case reviews and education within XR headsets, and ConveyXR™ for patient engagement and informed consent. The platform enables surgeons to visualize patient-specific anatomy, identify critical structures (nerves, blood vessels), and simulate complex procedures before entering the operating room. Deployed at leading academic medical centers including Mayo Clinic, Stanford, Mount Sinai, Houston Methodist, UCSF, and NYU Langone, among others. The technology derives from advanced flight simulation methodologies applied to surgical visualization. Regulatory status and specific FDA clearances not explicitly stated on fetched content, though clinical research studies referenced. Serves both academic and community hospital markets internationally.

DIXI Medical is a specialized neurosurgical device manufacturer with over 50 years of expertise in stereotactic electroencephalography (SEEG) systems and functional neurosurgery. The company develops high-precision intracerebral electrodes, intraoperative neurophysiological monitoring systems, and stereotactic implantation accessories for epilepsy diagnosis, treatment, and brain research applications. Core product lines include MICRODEEP® SEEG electrodes (sterile, single-use with up to 18 contacts and 0.8 mm diameter for deep brain exploration and thermocoagulation), MICRODEEP® Micro-Macro electrodes (for simultaneous multi-scale neuronal recording bridging clinical and research use), and Cortical IOM electrodes for intraoperative real-time cortical monitoring and stimulation. The company also manufactures dedicated stereotactic implantation instruments and accessories. DIXI Medical serves epilepsy centers and functional neurosurgery programs in over 40 countries and supports SEEG training and research initiatives globally. Manufacturing capabilities include microtechnical precision engineering, sterilization, and quality assurance aligned with medical device standards. The company emphasizes clinical collaboration with neurosurgeons, neurologists, and researchers, with field-based clinical support teams and ongoing investment in training programs for healthcare professionals. Products are designed for compatibility with robotic stereotactic systems and are used in both surgical and research settings.

Carlsmed is a publicly traded medical technology company specializing in AI-enabled personalized spine surgery solutions. The company's flagship aprevo® platform integrates artificial intelligence and 3D printing technology to design custom titanium spinal implants and deliver detailed, patient-specific surgical plans. The platform includes 3D surgical planning and visualization (myaprevo®), personalized procedural protocols, and biomechanically optimized implants designed to promote fusion. FDA-cleared for lumbar and cervical spinal fusion procedures, Carlsmed has completed over 50 cases. The company targets the substantial U.S. market opportunity of approximately 445,000 annual lumbar spine fusion procedures. With strong clinical evidence foundation and ISO 13485 certification, Carlsmed is expanding internationally following its July 2025 IPO.

AA Medical, operating as AA Medical Store, is a leading distributor of new and reprocessed medical equipment specializing in the aftermarket medical device resale sector. Founded in 2010 and headquartered in Mokena, Illinois with operations in Miami, Florida, the company supplies a comprehensive range of surgical and diagnostic equipment through an extensive network of 350+ sales representatives and relationships with 2,800+ healthcare facilities. AA Medical offers one of the largest online inventories of minimally invasive surgical equipment, endoscopy systems, orthopedic instrumentation, and surgical visualization technology at competitive, cost-optimized pricing. The company specializes in pre-owned and post-lease equipment across endoscopy, orthopedics, anesthesia, urology, and gynecology, emphasizing sustainable sourcing and white-glove customer service. Key product categories include visualization systems, surgical power instruments, laparoscopy and arthroscopy equipment, orthopedic implants and tools, patient monitoring and care devices, operating room infrastructure, and laboratory equipment from trusted manufacturers including Stryker, Arthrex, Conmed, Olympus, and Karl Storz.

PolarisAR Inc. develops mixed-reality surgical guidance technology for orthopedic procedures. The company's flagship product, STELLAR Knee, is a mixed-reality surgical navigation system designed for Total Knee Arthroplasty (TKA) procedures. STELLAR Knee delivers real-time, targeted surgical guidance directly onto the surgical field, enabling surgeons to simultaneously view patient anatomy and critical data. The system provides robot-like precision without the complexity or cost of conventional robotic surgery platforms. Key differentiators include seamless operating room integration with no requirement for external monitors, cameras, or towers; intuitive hand gesture and voice command control within the mixed reality environment; and compatibility with any implant system, allowing surgeons to select preferred implants while maintaining procedural flexibility. STELLAR Knee is designed to democratize access to advanced surgical technology by minimizing infrastructure costs and supporting diverse surgical workflows. The system functions as a digital surgical assistant, enhancing surgeon proficiency, workflow efficiency, and situational awareness during knee arthroplasty. PolarisAR targets orthopedic surgeons and surgical centers seeking precision guidance technology that balances advanced capability with cost-effectiveness and operational simplicity.

Centerline Biomedical develops intraoperative navigation technology for endovascular and interventional procedures. The company's flagship product, IOPS® (Intra-Operative Positioning System), is a 510(k)-cleared navigation platform that provides real-time 3D color image guidance as an alternative to conventional X-ray fluoroscopy. IOPS® is designed to mitigate occupational and patient radiation exposure in interventional cardiology, vascular surgery, and complex endovascular procedures. The system offers interactive navigation, high-quality 3D imaging, and portability compared to traditional 2D fluoroscopy-based guidance. Clinical evidence presented on the site documents significant occupational hazards associated with fluoroscopy exposure, including radiation-induced cataracts, brain tumors, and orthopedic issues among interventionalists. IOPS® targets procedures estimated at 4 million annually in the United States. The company collaborates with major medical institutions including Cleveland Clinic, the U.S. Air Force 59th Medical Wing, and the U.S. Army Institute of Surgical Research, indicating validation in both civilian and military surgical settings. The technology is positioned for vascular surgeons, interventional cardiologists, and trauma surgeons performing endovascular therapy, aortic procedures, and complex case management where radiation dose is a clinical and occupational concern.

Intellijoint Surgical is a Canadian medical technology company that develops and commercializes surgical navigation solutions for total joint replacements, including hip and knee arthroplasty. The company provides both pre-operative planning software and intraoperative navigation systems designed to improve surgical accuracy, reduce outliers, and enhance patient outcomes. Intellijoint VIEW is a web-based surgical planning platform that enables functional cup planning, implant templating, and coronal alignment planning without requiring CT imaging, with support for mechanical, kinematic, and restricted kinematic alignment targets. Intellijoint HIP delivers real-time intraoperative implant measurements for primary and revision total hip arthroplasty procedures. Intellijoint KNEE provides intraoperative measurement capabilities, instrumentation alignment guidance, and bony cut positioning assistance for knee replacement implantation. The solutions target orthopaedic surgeons, surgical care teams, and healthcare administrators seeking affordable, user-friendly navigation technology that reduces complexity and cost compared to traditional systems. The company serves the US and Canadian markets and has established strategic partnerships to expand orthopaedic procedural capabilities. Products are designed for ease of use and accessibility across varying surgical facility types and surgeon experience levels.

EchoPixel develops a software platform that converts standard medical imaging data into interactive 4D holographic visualizations for surgical planning and intraoperative guidance. The platform creates patient-specific digital twins that physicians experience as real physical objects without requiring headgear or glasses, enabling precise visualization of complex anatomical relationships during minimally invasive procedures. The technology is particularly applied in structural heart and congenital heart interventions, providing real-time situational awareness of catheters and implantable devices relative to patient anatomy. The company's core offering addresses limitations of traditional 2D and 2.5D imaging by reducing procedure complications and expanding access to minimally invasive therapies. EchoPixel's solution is FDA 510(k) cleared and deployed in leading hospital systems. The platform serves as a turnkey surgical guidance system that integrates with existing hospital imaging workflows, designed for cardiology, interventional radiology, and cardiac surgical teams. Manufacturing and software development capabilities are based in San Jose, California.

View Point Medical is a medical device company developing the OneMark Detection Imaging System, a surgeon-centric localization and imaging platform designed to detect and visualize visually enhanced markers placed during biopsy for precise tissue resection. The system enables intraoperative detection of marked lesions, particularly in breast cancer surgery, eliminating the need for preoperative localization device placement and reducing re-excision rates. The OneMark system represents a workflow innovation that decouples radiology and surgical scheduling while improving clinical and economic outcomes through simplified, minimally invasive localization. The company is focused initially on breast cancer indications with development underway for additional oncologic applications. Founded by experienced medical device entrepreneurs and clinical innovators, the company has assembled a leadership team with expertise in minimally invasive surgery, regulatory affairs, and medical device commercialization. The regulatory team brings over 40 years of FDA navigation experience.

Circinus Medical Technology (operating as Bolt Navigation) designs and manufactures the Bolt Navigation System, a handheld, surgeon-controlled surgical navigation device for spine surgery. The system employs gyroscope-on-chip technology to provide accurate real-time guidance for pedicle screw placement and other spinal instrumentation procedures. Unlike conventional navigation platforms requiring expensive capital equipment, extensive imaging, or technician support, Bolt integrates seamlessly into existing OR workflows with minimal setup and zero footprint. The device is implant-agnostic, reducing radiation exposure for surgeon and patient while eliminating the need for preoperative registration or external imaging. Bolt operates on a flexible subscription model rather than capital purchase, making it particularly accessible to ambulatory surgery centers (ASCs). The system is designed to enhance surgical accuracy, improve workflow efficiency, reduce operative time, and lower total cost of ownership. The company targets surgeons and surgical teams across hospital systems and ASCs seeking radiation-reduced, cost-effective navigation without major infrastructure investment.

nView medical develops intraoperative 3D imaging and surgical navigation systems designed to enhance safety, speed, and accuracy in operating room procedures. The company's flagship product, the nView s1™, combines low-dose 3D imaging capture with true-map navigation™—a GPS-like surgical guidance system that uses real anatomical images as navigation maps. The system integrates imaging, tracking, and AI technologies to provide surgeons with intraoperative planning, real-time guidance, and quality control capabilities. Originally developed for pediatric surgery, the nView s1 has expanded into adult spine surgery applications. The platform is FDA 510(k) cleared and has been deployed in leading pediatric institutions including Scottish Rite for Children and St. Louis Children's Hospital. As of March 2025, nView medical has completed over 500 surgical procedures. The management team brings extensive experience from GE Healthcare in imaging and navigation technologies. The company pursues partnerships with established medical device organizations, including a strategic investment and partnership with Orthofix announced in January 2022.

Ziehm Imaging GmbH is a Germany-based manufacturer of intraoperative mobile C-arm imaging systems and related software solutions for surgical guidance and case planning. The company's core product portfolio includes mobile C-arm fluoroscopy systems (Ziehm Vision RFD 3D, Ziehm Vision RFD Hybrid Edition, Ziehm Vision FD, Ziehm Solo FD) designed for orthopedic, vascular, cardiac, and general surgical applications. Ziehm operates through subsidiaries including Therenva SAS, which develops advanced planning and navigation software (EndoSize for preoperative planning, EndoNaut for intraoperative vascular navigation with image fusion). Key differentiator: SmartDose technology for dose-optimized imaging. Products deliver real-time fluoroscopic guidance with emphasis on dose reduction and image quality. Systems support 2D and 3D imaging, video endoscopy integration, and intraoperative image fusion with preoperative CT/MR data. Ziehm serves orthopedic, hand surgery, vascular/endovascular, cardiac intervention, and interventional pulmonology markets globally. US operations headquartered in Orlando, FL with nationwide service network. Company exhibits at major surgical conferences (FESSH, Charing Cross, CX Symposium) and publishes clinical evidence and case studies. CE-marked and FDA-cleared devices. Global distribution through network of regional partners and direct sales.

Brainlab is a Munich-headquartered medical technology company specializing in digital surgical ecosystems, robotic-assisted surgery, and intraoperative imaging platforms. The company designs integrated software and hardware solutions for neurosurgery, orthopedic spine surgery, radiosurgery, and craniomaxillofacial procedures. Core product lines include the Brainlab Robotic Suite (robotic-assisted surgical systems), Loop-X (mobile robotic intraoperative CBCT imaging), Spine Mixed Reality Navigation, spinal planning software, Elements (radiosurgery planning and automation), and Craniomaxillofacial Planning software. Brainlab also manufactures surgical navigation systems, mixed-reality visualization platforms, and ultrasound-based intraoperative guidance tools. The company markets solutions globally to hospitals and surgical centers, supporting minimally invasive and open procedures. Regulatory credentials include CE marking and FDA clearances; the site references 510(k) submissions and compliance with international standards. Brainlab operates worldwide with headquarters in Munich-Riem, Germany, and maintains regional presence across North America, Europe, and Asia-Pacific. The company emphasizes end-to-end surgical ecosystem integration, enabling preoperative planning through intraoperative execution and has partnerships with academic medical centers and large health systems.

Waypoint Orthopedics is a spine surgery medical device company founded by Dr. Stephen Banco and backed by Runway Healthcare, LP. The company specializes in vertebral fixation systems designed to reduce radiation exposure and enhance surgical efficiency in open and minimally invasive spine procedures. Waypoint's primary product is the GPS (Guided Pedicle System), an FDA-approved surgical navigation system that provides real-time intraoperative guidance for pedicle screw placement. The system addresses a critical occupational health concern: spine surgeons routinely exceed their lifetime radiation exposure limits within the first decade of practice, experiencing up to 12 times higher radiation exposure than other fluoroscopically-assisted surgical specialties. The GPS system enables more confident pedicle screw positioning while substantially reducing radiation exposure to surgeons, operating room staff, and patients. The company's regulatory credentials include FDA approval for use in both open and minimally invasive spine (MIS) surgery. Leadership includes seasoned medtech executives, with clinical guidance from a surgeon advisory board comprising experienced spine surgeons. Waypoint targets hospital and ambulatory surgical center OR environments performing routine spinal fusion and stabilization procedures. The company positions its technology at a large addressable market—approximately 1.62 million spine surgeries annually in the United States—where pedicle screw fixation is a standard technique.