Clinical Software in Minnesota

Reflex Medical Corp is a medical device contract manufacturing and development partner serving device manufacturers across product lifecycle stages. The company provides comprehensive in-house capabilities spanning product design, engineering, research and development, rapid prototyping, small-batch to high-volume production, secondary operations, and finishing services. Operating under a single-roof integration model, Reflex Medical enables manufacturers to optimize throughput, explore product differentiation opportunities, and maximize manufacturing investments. The company also serves as a wholesale distributor and authorized service provider for GAKO Unguators, EMP jars, and accessories in North America, offering repair and maintenance services for these specialized devices. Reflex Medical previously manufactured and distributed UnoDose™, a pharmaceutical dispensing device, though this product line was acquired by Topi-CLICK in 2025. The organization combines extensive in-house expertise with state-of-the-art facilities and a demonstrated track record in medical device manufacturing. Capabilities include design optimization, process efficiency consulting, prototyping, and full-scale production support for device companies seeking to outsource manufacturing operations or augment existing in-house capabilities.

Solventum is the standalone healthcare business formerly part of 3M Company, headquartered in Eden Prairie, Minnesota. The company operates across five major business segments: Medical (including advanced wound care, patient warming, and surgical solutions), Oral Care (dental restoratives and orthodontic products), Health Information & Technology (clinical software and data analytics solutions), Filtration & Engineering (laboratory and manufacturing filtration systems), and Patients & Consumers (over-the-counter health and wellness products). Key product lines include Solventum™ V.A.C.® Therapy (negative pressure wound therapy systems), Filtek™ dental restoratives, and comprehensive health information technology platforms designed to improve clinical decision-making and operational efficiency. The company serves healthcare providers, dental professionals, laboratories, and consumers globally, with a 70-year legacy of innovation spanning material sciences, data analytics, and clinical solutions. Solventum recently completed the acquisition of Acera Surgical, adding advanced wound care technology (Restrata®) to its portfolio. The company maintains robust manufacturing and quality engineering capabilities across multiple facilities in the US, including recent expansions in Minnesota and South Dakota. Products are developed to meet healthcare regulatory standards including FDA approvals for medical devices and consumables.

Dose Health is a Minnesota-based provider of assistive technology and remote monitoring solutions for medication management and personal emergency response. The company specializes in connected devices and cloud-based services designed for homecare, residential facilities, and individuals requiring medication adherence support or emergency alert capabilities. Core Product Lines: 1. Dose Flip: An automated smart pillbox system that dispenses medications at scheduled times, with visual and audio alerts. Supports flexible medication schedules (1–4 times daily). Includes caregiver notifications if doses are missed or taken improperly. Priced at $60/month. 2. Dose Remind: A medication reminder service (specific details limited in available content). 3. Personal Emergency Response Systems (PERS/+): - Belle X, Belle W, Teardrop, Stride Watch: Wearable/portable emergency alert devices ($45/month each) - Belle: Standard PERS device ($30/month) All devices operate via cellular data; no Wi-Fi required. Market Focus: Dose Health targets residential care facilities, home health agencies, caregivers, and individuals in homecare settings. The service is covered by many HCBS (Home and Community-Based Services) Waivers, indicating emphasis on Medicaid/subsidized populations. Marketing emphasizes workforce shortage mitigation—enabling single caregivers to oversee multiple residents remotely while ensuring medication compliance. Technical & Regulatory: NPI: 1891155909 (National Provider Identifier issued) Operates via cellular networks (LTE). Processing turnaround stated as less than one day. Offers 30-day free trial across all services. Service Model: Subscription-based monthly recurring revenue model. Referral/ordering and monitoring conducted through cloud dashboard (app.dosehealth.com). Customer support available by phone (844-300-6212) and email.

Midwest Interventional Systems (MIS) is a vertically integrated, FDA-registered medical device contract manufacturer and design partner specializing in catheter systems and minimally invasive device components. The company designs and manufactures custom medical balloons (non-compliant, semi-compliant, and compliant variants) and medical extrusions (single-lumen to complex multilumen tubing) for interventional and endovascular applications. MIS serves 100+ minimally invasive device companies spanning neurovascular, atrial fibrillation, endoscopy, and other specialties. The company operates three core business units: Components (off-the-shelf and custom balloons and extrusions via online design tools), Design Services (concept-to-commercialization catheter engineering with a dedicated Co-Lab for rapid prototyping), and Manufacturing (pilot through full-scale contract manufacturing with in-house capabilities). Key offerings include IQueue (proprietary online extrusion designer for rapid custom ordering), Balloon Designer, Catheter Designer, and an online component store with 24-hour shipping and $50 minimum orders. MIS maintains ISO 14385:2016 certification and FDA registration. The company employs catheter engineers with 10+ decades of combined expertise and follows a proven 5-phase development methodology. Notable clients and testimonials reference work with neurovascular innovators, endoscope manufacturers, atrial fibrillation device companies, Mayo Clinic physician innovators, and leading MedTech firms.

BioMedix (Collaborative Care Diagnostics, LLC) is a vascular diagnostics company founded in 2004 specializing in non-invasive physiologic assessment systems for identifying peripheral artery disease (PAD) and managing population health in value-based care settings. The company's primary product line includes PADnet, a flexible and customizable vascular assessment system designed for clinical settings to detect hidden peripheral vascular disease through non-invasive testing, and PADnet Xpress, a portable, rapid screening solution optimized for population health management. BioMedix Xchange is a population health management platform that aggregates test results and patient history for centralized analysis and specialist review. The company enables secure remote transmission of test data and patient information to specialists for interpretation, supporting distributed care models and reducing patient travel burden. PADnet systems are used by podiatrists, primary care physicians, vascular surgeons, cardiologists, and interventional specialists across physician practices, hospitals, and health systems. Products integrate with multi-specialty groups to streamline workflow and improve care coordination between primary physicians and specialists. The company emphasizes training and support for clinical staff to ensure proper testing protocols and diagnostic confidence. Applications include screening high-risk populations (diabetics, smokers, patients over 65), evaluation of intermittent claudication and limb pain, identification of candidates for revascularization procedures, and ongoing management of vascular disease in value-based payment models. The platform supports seamless sharing of diagnostic results across care networks and remote specialist interpretation via secure internet-based systems.

Healthcare Tech Solutions is a specialized medical imaging IT consulting and services firm serving healthcare organizations nationwide. The company provides comprehensive DICOM data migration services, PACS administration and support, VNA (Vendor Neutral Archive) consulting, and enterprise imaging management. Core service offerings include self-managed and full-service DICOM migrations, SCO-to-BTO and CTO-to-BTO breast imaging conversions, PACS system implementation advisory, and staffing solutions with vetted medical imaging professionals. The company also supplies diagnostic displays/monitors, media systems, and medical imaging hardware. Founded by former PACS administrators, Healthcare Tech Solutions addresses challenges in data integration during hospital mergers and acquisitions, legacy system conversions, and imaging workflow optimization. The firm offers strategic guidance, implementation project management, infrastructure design, and ongoing technical support to streamline operations and enhance patient care while reducing costs and operational disruptions.

Premier Biotech is a drug testing and diagnostics company offering integrated rapid and laboratory-based testing solutions. The company manufactures and operates OralTox®, a rapid oral fluid drug test recognized as the #1 brand in rapid oral fluid testing, paired with OT-Scan®, a digital results interpretation and reporting application for point-of-collection testing. Premier Biotech operates two CAP-accredited forensic laboratories (Minneapolis and Scottsdale) and SAMHSA-certified facilities supporting confirmatory testing and regulated drug testing programs. The company serves employers, healthcare providers, government agencies, background screening partners, and public-sector organizations across workplace testing, clinical testing, and government/criminal justice applications. Product lines include rapid oral fluid tests, lab-based oral fluid collection (Intercept i2he®), rapid urine screening, SAFE harm reduction test strips (detecting fentanyl, xylazine, nitazenes, benzodiazepines), and Premier Biotech Services (PBS), a full-service program administration offering including drug testing, background screening, reporting, and program management. The company emphasizes observed collection workflows, chain-of-custody procedures, customizable drug panels, and integrated end-to-end testing ecosystems. With nearly 20 years of experience in rapid diagnostics development, Premier Biotech positions itself as a stable, regulated partner with structured onboarding, training, and customer success support for compliance-driven and safety-sensitive environments. 510(k)-cleared devices are available with up to 8 drug panels.

NeckCare develops objective assessment and rehabilitation systems for cervical spine dysfunction. The company manufactures the NeckCare System™, a wearable sensor device with Bluetooth connectivity paired with a web-based clinical platform, used by over 250 providers across North America to evaluate and treat patients with neck pain, headaches, concussion, whiplash-associated disorders, and dizziness. The system measures cervical range of motion, proprioception (joint position sense), and sensorimotor control through the proprietary Butterfly Test®. The NeckCare Platform automates assessment protocols, generates normative data comparisons, and enables real-time progress tracking. NeckCare Home™ is a camera-powered remote rehabilitation extension requiring no additional hardware beyond a standard personal device camera. The system is FDA-listed and incorporates decades of clinical research. Primary markets include physical therapy clinics, chiropractic practices, sports medicine facilities, and academic medical centers. The system generates objective documentation supporting clinical decision-making and insurance claim substantiation. Customers include University of Miami, Johns Hopkins Medicine, and UFC Performance Institute.

Voltas Medical LLC is a vertically integrated medical device development and manufacturing partner headquartered in Cottage Grove, Minnesota. The company provides accelerated, end-to-end services for medical device commercialization under a single project manager, budget, and timeline. Core capabilities span R&D and rapid weekly prototyping (using Arduino, Raspberry Pi, sensors, LCD screens), regulatory services (510k submissions, PreSub/513g work), contract manufacturing (plastic injection molding, micro-molding, die-mold tooling), specialized processes (balloon development, hydrophilic/hydrophobic coatings, UV laser etching, RF and ultrasonic welding), in-house ETO sterilization with validation, packaging and blister tray development, and post-launch support including distribution, warehousing, medical sales, and marketing. The company targets Class I and Class II medical devices and claims capability to bring products to market in under 2 years for under $1 million. Device specialties include ablation catheters, stent delivery systems, diagnostic imaging, laparoscopic instruments, bone plates, endovascular grafts, neurostimulation devices, and vascular catheters.

Ōmcare is a digital health technology company headquartered in Bloomington, Minnesota, specializing in medication management and remote care solutions for aging and complex chronic populations. The company's flagship product, the Ōmcare Home Health Hub®, is a comprehensive platform that integrates automated medication dispensing, telehealth infrastructure, biometric monitoring, care coordination, and family communication in a single, senior-friendly device. The Hub dispenses pre-packaged medications at scheduled times with multi-camera visual verification to confirm adherence, while enabling one-touch video connectivity between patients, family members, and healthcare providers. The system operates through a turnkey Medication Assistance Service model, where home care agencies install the device and load monthly pre-sorted pharmacy deliveries. Ōmcare targets healthcare organizations, home care agencies, and family caregivers seeking to improve medication adherence, reduce costs, and extend quality care into the home setting while maintaining professional oversight and patient independence.

Dosentrx is a health technology company founded in 2011, specializing in remote medication adherence solutions for specialty drugs, particularly in oncology and complex therapies. The flagship product, ReX, combines a reusable smart drug dispensing device with a cloud-based portal to monitor patient medication adherence, provide real-time adherence data, and deliver personalized patient guidance—functioning as a remote digital nurse. The ReX system is provided at no cost to patients through specialty pharmacy partnerships and is FDA Class III cleared and HIPAA compliant. Dosentrx also offers Dose-E, an intelligent cloud platform for enhanced patient engagement and clinical data analytics. The platform has demonstrated real-world impact with 186,000+ pills administered and 88,000+ patient-reported outcomes captured. Designed to optimize healthcare workflows and support value-based care, Dosentrx serves pharmaceutical manufacturers, specialty pharmacies, and healthcare providers seeking to improve patient safety, medication traceability, and therapy outcomes.

Radiometer Medical APS is a global acute care diagnostics company with over 70 years of industry experience. The company manufactures and integrates blood gas analyzers, point-of-care testing syringes, point-of-care IT solutions, and associated laboratory services. Operating across 59 countries with 3,780+ employees, Radiometer's portfolio addresses critical diagnostic workflows in hospitals and acute care settings. The company reports testing approximately 300,000 samples daily with its products, impacting approximately 4 million patients annually. Radiometer's core offerings include automated blood gas testing systems, integrated IT platforms for regulatory compliance and data management, and consumable supplies for acute care diagnostics. The company serves hospital networks, emergency departments, and intensive care units seeking standardized, automated diagnostic workflows. Radiometer operates as part of Danaher Corporation and maintains a customer portal using Microsoft Azure AD authentication, indicating enterprise-level software and data security infrastructure. The company's mission emphasizes streamlining diagnostic workflows to enable clinicians to focus on patient care in critical settings.

Nextern Innovation is a vertically integrated medical device contract design, development, and manufacturing organization (CDMO). The company collaborates with innovators and clinicians to design, develop, optimize, and manufacture medical devices across multiple therapeutic areas. Nextern operates four global manufacturing facilities totaling 250,000 square feet, including 20,000 square feet of cleanroom space, with a team of 600+ members worldwide. The company specializes in minimally invasive devices, single-use catheter and metal assemblies, Class III active implantable leads and delivery systems, power systems (catheter and generator development), bioelectronics, and connected care solutions. Nextern Liink, a subsidiary, develops custom, secure, and scalable software solutions for medical device connectivity. Core capabilities include device design and development (bio-simulation, pre-clinical testing, IP support), full-spectrum manufacturing with phased transition from development to commercialization, supply chain management, and life-cycle services including warranty and continuous improvement. The company operates virtual quality management systems and maintains presence in strategically located global manufacturing locations with localized supply chains. Nextern serves cardiology, neuromodulation, and other specialty device markets, with demonstrated expertise in brain-computer interfaces and platforms for labeling and graphical user interfaces.

YourSteps Health develops a cloud-based pediatric rehabilitation platform designed to extend therapy beyond clinic walls. The platform integrates physical therapy, occupational therapy, and speech-language pathology into a unified digital health solution for children ages 0–18. The platform comprises two main components: a therapist portal for care coordination, remote progress monitoring, exercise library management, and secure caregiver messaging; and a patient/family mobile app featuring age-appropriate exercise videos, progress tracking, smartphone-enabled physical ability challenges, and gamified rewards to enhance compliance. Key capabilities include real-time data-driven insights with early intervention alerts, comprehensive documentation for remote therapeutic monitoring (RTM) billing and compliance, and customizable content integration allowing facilities to add hospital-approved materials. The solution addresses fragmentation in pediatric rehabilitation by consolidating PT, OT, and SLP needs in one integrated system, improving continuity of care and enabling therapists to adjust programs remotely rather than relying on generic external resources. YourSteps is widely adopted in pediatric hospitals, rehabilitation facilities, and therapy service providers across the United States. The platform received the 2024 APTA Pediatrics Practice Fair Innovation Award. The company operates as a B2B SaaS solution targeting rehab managers, therapists, and pediatric healthcare systems seeking to improve outcomes and operational efficiency.

OneDose is a comprehensive EMS (Emergency Medical Services) patient care platform delivering AI-native protocol management and medication safety decision support from pre-scene to hospital handoff. The platform equips frontline paramedics and EMTs with real-time medication dosing calculations, patient-weight hardware integration (OneWeight), and clinical decision guidance to reduce cognitive errors and improve patient outcomes. The system includes an admin console for protocol customization, user permission management, and compliance tracking. OneDose serves fire departments, ambulance services, hospital EMS systems, and regional medical control consortiums across the United States. Core features include standardized medication dosing protocols with built-in cross-checks, seamless integration with electronic patient care records (ePCR) and dispatch systems, real-time decision support for high-acuity scenarios (pediatric emergencies, complex protocols), and liability reduction through documented standardized workflows. The company emphasizes ease of implementation, minimal training overhead, and scalable licensing tiers. Designed by EMS clinicians for field deployment in high-pressure, unpredictable environments. Regulatory credentials and FDA status not specified in available content.

Nonin Medical, Inc. is a global leader in designing and manufacturing noninvasive physiological monitoring solutions. Founded in 1986 and headquartered in Plymouth, Minnesota, the company serves clinicians and consumers in over 125 countries. Nonin pioneered the world's first portable hand-held pulse oximeter and fingertip pulse oximeter, and was the first to integrate Bluetooth technology in pulse oximetry devices. The company's core product portfolio includes pulse oximeters (fingertip, wrist-worn, and handheld), regional/cerebral/somatic tissue oximeters, capnographs, and associated sensors. Nonin's proprietary PureSAT pulse oximetry technology provides accurate readings even in challenging conditions with motion, low perfusion, or variable skin tones. Primary customers include emergency medical services, hospitals, clinics, long-term care facilities, home healthcare providers, and OEM manufacturers who integrate Nonin components into their own medical devices. The company recently introduced the Nonin Health® platform, a cloud-based data management system enabling remote access to pulse oximetry results for improved workflow efficiency and clinical decision-making.

EmpNia Inc. is a medical device company specializing in precision image-guided radiation therapy (IGRT) motion management. The company manufactures EmpNia eMotus, an FDA-cleared wearable fiber optic sensing solution designed to dynamically track and manage respiratory motion during cancer treatment. The eMotus system combines a wearable fiber optic sensor with integrated software to enable real-time patient motion detection, ensuring consistent and confident treatment delivery across diverse patient presentations. The technology is system-agnostic and universally compatible with existing radiation therapy platforms, requiring no capital equipment purchase—operational on a service model. Key features include fast seamless integration into clinical workflows, cost-effective deployment, and closed-loop feedback to radiation oncology teams. The solution addresses a critical clinical need in precision oncology by reducing treatment uncertainty due to respiratory motion, thereby improving targeting accuracy and patient safety. EmpNia targets radiation oncology departments and cancer treatment centers seeking advanced motion management capabilities without substantial infrastructure investment.