What does the OneRF® Radiofrequency Ablation System cost?

Pricing remains proprietary; early-stage market shows limited public data

The OneRF® Radiofrequency Ablation System is indicated for creation of radiofrequency lesions in nervous tissue for functional neurosurgical procedures. As a 510(k)-cleared system that received FDA clearance in December 2023 , OneRF represents a specialized, high-complexity neurosurgical platform. Unlike mature RF ablation markets for pain management or oncology, the OneRF system does not have publicly available list pricing. This article captures what is currently known about acquisition costs and provides context from comparable RF systems.

What the typical range likely is

MedSource does not yet have direct quote data for OneRF. The system is in early commercial deployment (limited launch phase as of May 2026), with active installations at only a handful of academic medical centers including Mayo Clinic Florida and University Hospitals Cleveland.

For perspective on RF generator systems more broadly, observed public list prices for radiofrequency ablation generators range from approximately $38,000 for the Boston Scientific RF 3000 to $55,000 for the Stryker Sonicision multi-channel system . However, these are general-purpose pain-management and oncology RF systems, not specialized neurosurgical thin-film electrode platforms.

Federal procurement awards via GSA Advantage show realized prices between $28,000 and $52,000 per generator. Given OneRF's clinical differentiation— the system is the first and only FDA-approved interface that enables surgeons to choose the electrode to ablate —capital acquisition costs are likely to position above commodity RF generators but below fully customized surgical systems.

Expected range: $40,000–$75,000 for the generator unit (based on comparative market positioning). This is an inference, not a confirmed quote. Request pricing directly from NeuroOne or authorized distributors.

What pushes price up — features, certifications, support tier

Proprietary RF generator with real-time temperature control. OneRF includes a customized radio frequency (RF) generator with real-time temperature monitoring capabilities , which adds engineering complexity and regulatory validation cost versus off-the-shelf platforms.

Thin-film sEEG-RF electrode integration. The system's thin-film sEEG-guided RF capabilities enable the surgeon to both record electrical activity and ablate nervous tissue; temperature control is achieved via the system's proprietary Evo® sEEG-RF probe. This dual-function electrode is a patented innovation—not a repackaged or licensed component. Development and IP licensing increase entry cost.

Limited installed base and early-stage manufacturing. With only a handful of active sites, unit volumes remain low, reducing economies of scale in production and distribution. NeuroOne began a limited commercial launch of the OneRF Ablation System, being the first to market with a thin-film electrode technology capable of performing both diagnostic and therapeutic functions.

Clinical training and credentialing. Neurosurgeons using sEEG-guided RF ablation for epilepsy or trigeminal nerve pain require specialized training. Bundled training hours or on-site proctoring are typical cost additions ($5,000–$15,000 per site).

Service tier and support agreements. Early-stage devices often require longer-term service contracts and remote technical support. Annual maintenance may run 10–15% of capital cost ($4,000–$11,000/year).

What pushes price down — refurbished, older generation, lease, GPO contracts

Used or refurbished units. No secondary market yet exists for OneRF systems given the recent FDA clearance (December 2023) and limited install base. Expect refurbished options to emerge 3–5 years post-launch.

Bundled consumables pricing. Modeled price corridors indicate that realized transaction prices land at 50–80% of list after GPO/IDN discounts of 15–40% . If NeuroOne negotiates bundled electrode and generator contracts, buyers committing to multi-year consumables volumes may negotiate 20–35% discounts off list price.

Lease vs. purchase. Capital leasing for emerging surgical systems typically costs 24–36 monthly payments at 4–6% of list price per month (~$1,500–$3,500/month for a $60,000 system). This defers upfront expenditure and shifts obsolescence risk, but increases total cost-of-ownership over 5+ years.

Healthcare provider networks and GPOs. Once OneRF achieves broader adoption, health systems participating in GPOs (Vizient, Medline, Premier) may negotiate volume contracts. Current installed base is too small for meaningful GPO leverage.

Hidden costs — install, training, calibration, consumables, service contracts

Installation and site preparation: $2,000–$5,000. RF generators require clean power, electromagnetic interference shielding, and secure cabling in OR or bedside suites. Most vendors charge for site survey and validation.

Operator training: $5,000–$15,000. Neurosurgeons, neuromonitoring technicians, and OR nursing staff require hands-on training. OneRF allows for greater control during ablation procedures for patients with epilepsy, Parkinson disease, dystonia, and essential tremor, among others. Clinical applications are diverse; institution-specific training is non-negotiable.

Electrodes and consumables: $500–$2,000 per procedure. University Hospitals utilized six OneRF electrodes implanted in a separate procedure to conduct 44 separate ablations utilizing sEEG recordings. Each Evo® sEEG-RF electrode is single-use or limited-reuse. Per-case costs accumulate rapidly for active programs.

Annual service and support: $4,000–$11,000. Early-stage devices from venture-backed companies often include multi-year service agreements. Costs cover software updates, calibration verification, hardware inspection, and emergency support lines.

Reimbursement setup: $1,000–$3,000. New procedures require medical record template design, coding compliance, billing staff training, and insurance credentialing. OneRF's FDA approval could lead to revenue generation by late 2025 , but CPT codes and reimbursement pathways are still evolving.

How to negotiate — concrete tactics

1. Request itemized cost breakdowns. Ask NeuroOne or their distributor to separate capital cost, electrodes, training, service, and consumables. Bundled quotes obscure true cost-of-ownership.

2. Commit to multi-year electrode purchasing. Volume commitments (e.g., 50–100 procedures/year guaranteed for 3 years) can unlock 20–30% consumables discounts.

3. Leverage training bundling. Ask whether training is included in capital cost or billed separately. Negotiate flat-rate training vs. hourly labor rates; this saves $3,000–$8,000 for larger teams.

4. Benchmark against general RF systems. Before accepting a quote, compare to mainstream RF generators (Boston Scientific RF3000, Medtronic Cool-tip, Stryker systems) on feature-to-cost ratio. OneRF's specialization justifies a premium, but quantify the clinical benefit.

5. Ask about lease-to-own or trial periods. For early adopters, request 90-day evaluation agreements before committing to purchase. This allows clinical validation before capital commitment.

6. Negotiate service agreements separately. Don't accept 5-year service bundles at purchase time. Lock in Year 1 at 10–12% of capital cost, then renegotiate Years 2–5 based on actual utilization.

7. Coordinate with GPO or IDN. If your health system is part of Vizient, Premier, or Medline, ask whether OneRF (or its distributor) has GPO contracts. Leverage group purchasing power even in early adoption phase.

When the price feels off — red flags

• No itemized breakdown. If a vendor quotes a single all-in number without separating capital, service, training, and consumables, walk away. You cannot control costs you cannot see.

• Perpetual service lock-in. Avoid contracts requiring 5+ years of service or consumables commitments. Rapid innovation in thin-film electrodes could render long-term commitments obsolete.

• No reference sites. Demand contact info for 2–3 existing OneRF installations for independent cost validation. NeuroOne's limited customer base makes this difficult; if the vendor cannot provide references, pricing data is unverifiable.

• Pricing inconsistent across regions. For a proprietary device with centralized manufacturing, significant regional variation (>25%) suggests either negotiated IDN discounts or opaque distributor markups. Investigate distributor agreements.

• Hidden electrode costs. If the generator price seems low but electrodes cost $1,500+ per case, you're seeing loss-leader pricing on capital. Recalculate total 5-year cost including 50–100 procedures/year.

• Training "extra. Clinical training should be bundled; if quoted separately, the capital price is inflated. Request combined quotes.

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Sources

NeuroOne OneRF® Radiofrequency Ablation System product indication and FDA Clearance (K231675) , NeuroOne Medical Technologies, accessed May 2026.

Radiofrequency Ablation Generators market data: list prices and GSA procurement pricing , IndexBox Market Intelligence, March 2026.

Case study: University Hospitals Cleveland clinical use of OneRF system , University Hospitals, December 2024.

NeuroOne OneRF commercial launch timeline and FDA 510(k) clearance , Medical Device Network, March 2024.

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Article Status: This article will be updated as MedSource collects direct quotes from health systems and vendors. Current pricing remains proprietary and inference-based. For verified acquisition costs, contact NeuroOne Medical Technologies directly or request RFQ responses from authorized distributors.