Signifier Medical Technologies LLC

Signifier Medical Technologies (formerly eXciteOSA) develops non-invasive daytime therapies for snoring and sleep-disordered breathing, including obstructive sleep apnea (OSA). The company's flagship product, eXciteOSA, is a novel intraoral tongue stimulator device that physiologically retrains the airway to prevent collapse, addressing the root cause of sleep disordered breathing rather than merely treating symptoms. Unlike conventional treatments (CPAP, oral appliances, positional devices) that must be worn during sleep and often suffer from poor compliance and comfort issues, eXciteOSA is used as a daytime therapy for 20 minutes once daily over a 6-week treatment period. The device targets mild-to-moderate sleep apnea and snoring patients with significant unmet medical needs. Clinical data from a prospective cohort study (n=50, 46 completers) demonstrated 98% of patients reported reduction in snoring time and 82% of bed partners reported partner snoring reduction, measured objectively via WatchPAT sleep studies. The company was founded by Professor Akhil Tripathi, a serial medical device entrepreneur with expertise in sleep medicine, maxillofacial surgery, and regulatory compliance. Manufacturing and regulatory capabilities span product development, medical engineering, software development, and medical device regulatory expertise. The device addresses a large global market of patients with snoring and mild OSA who discontinue or avoid conventional therapies due to discomfort, inconvenience, or sleep disruption.