Piccolo Medical, Inc.

Piccolo Medical designs and manufactures guidance systems for peripherally inserted central catheter (PICC) and central venous catheter (CVC) placement. The company's flagship products—PM2+™ System and ECGuide®—use intravascular electrocardiogram (ECG) technology combined with ionic dilution sensing to enable bedside confirmation of catheter tip positioning, eliminating the need for post-placement chest X-ray confirmation. The PM2+™ System features the Nav+™ stylet with machine learning-powered navigation feedback delivered via a mobile app; setup takes under 90 seconds and provides real-time guidance during catheter insertion. ECGuide® is cleared for use in adult, pediatric, and neonatal patients and has been shown to improve placement accuracy and reduce complications including thrombosis and malposition. The technology addresses a significant clinical and operational problem: approximately 50% of PICCs placed without guidance are malpositioned, requiring confirmatory imaging that adds cost, radiation exposure, and procedure time (average 78-minute wait for chest X-ray). Piccolo Medical is FDA 510(k) cleared and has received funding from the National Institute on Aging (NIA) and other federal agencies. The company serves hospitals and healthcare systems focused on improving catheter placement safety and reducing procedural delays.