Nuwellis, Inc.

Nuwellis, Inc. is a commercial-stage medical device manufacturer specializing in ultrafiltration therapy systems for fluid management in cardiorenal patients. Founded in 1999 and headquartered in Eden Prairie, Minnesota, the company develops and markets the Aquadex FlexFlow System and Aquadex SmartFlow System—precision ultrafiltration devices designed to remove excess fluid in patients with heart failure, acute kidney injury, chronic kidney disease, and cardiorenal syndrome when diuretics prove inadequate. The systems deliver predictable, isotonic fluid removal while protecting organ function and reducing hospitalizations and readmissions. Nuwellis supports critical care, pediatric, nephrology, cardiology, and outpatient settings with comprehensive clinical evidence from 65+ peer-reviewed studies spanning 20+ years. The company provides integrated cardiorenal management solutions, clinical training, reimbursement support, and dedicated customer service to healthcare providers globally, addressing both acute perioperative fluid management and chronic disease management.