Operating Room Systems in California

RefleXion Medical develops biology-guided radiotherapy (BGRT) systems for cancer treatment. The company's flagship product, the RefleXion X1 machine with SCINTIX autonomous radiotherapy, combines PET (positron-emission tomography) imaging with linear accelerator (LINAC) radiation therapy to enable real-time tumor tracking and treatment delivery. SCINTIX detects biological signals emitted by cancer cells after radiopharmaceutical injection and uses this information to autonomously guide radiation beams to tumors in motion, potentially reducing dose to surrounding healthy tissue. The system is FDA-cleared for treatment of lung and bone tumors, including primary and metastatic disease at any stage. In addition to SCINTIX therapy, the RefleXion X1 platform delivers conventional radiotherapy modalities including SBRT (stereotactic body radiation therapy), SRS (stereotactic radiosurgery), and IMRT (intensity-modulated radiation therapy) for solid tumors throughout the body. The platform is designed to fit standard radiotherapy vaults with minimal shielding modifications and is compatible with third-party immobilization devices and existing contouring tools. Founded in 2009 by Sam Mazin, Ph.D. and Akshay Nanduri, RefleXion has secured over $400 million in venture financing and employs more than 250 people. Leadership includes Todd Powell (President and CEO, formerly of Elekta) and Martyn Webster (CFO). SCINTIX therapy has achieved Medicare reimbursement through multiple Medicare Administrative Contractors (MACs), supporting adoption in freestanding cancer centers and hospital outpatient departments. The company targets oncology departments, cancer centers, and radiation therapy facilities.

EIZO Corporation is a global manufacturer of professional display monitors and imaging solutions for medical, business enterprise, graphics, maritime, and air traffic control applications. The company specializes in medical-grade displays including the RadiForce line for diagnostic imaging, mammography, and PACS workstations; the CuratOR series for operating room visualization; and the ColorEdge series for color-critical professional work. EIZO designs and manufactures LCD monitors engineered for clinical accuracy, reliability, and specialized workflow integration in healthcare environments. Products include the RadiForce RX1270 and related diagnostic monitors, CuratOR operating room display systems, and DuraVision industrial monitors. The company serves hospitals, imaging centers, surgical suites, and enterprise organizations globally. EIZO maintains extensive support infrastructure including product registration, warranty programs, technical documentation, FAQs, manuals, driver updates, and compatibility tools. Distribution channels include direct sales, authorized resellers, distributors, and channel partners across North America. The company supports major medical imaging standards and integrates with clinical workflow systems for seamless hospital deployment.

JAM-Labs Corp is a medical technology company specializing in AI-powered surgical environment solutions and operating room integration systems. The company designs and manufactures hardware, software, FPGA, embedded systems, and mechanical solutions for perioperative environments. Their product portfolio includes advanced OR recording and visualization devices, integration systems, and intelligent digital platforms that enhance surgical workflows, patient safety, and OR efficiency. JAM-Labs serves hospitals and surgical centers with solutions designed for surgeons, nursing staff, trainees, and healthcare administrators. The company emphasizes real-time data insights, automation through AI algorithms, error prevention systems, and seamless integration with existing perioperative workflows. Their offerings address OR performance optimization, staff collaboration, surgical documentation, and procedure recording with high-resolution 4K visualization. JAM-Labs targets institutional healthcare markets and has demonstrated presence in catheterization labs and surgical suite environments, with customer testimonials from hospital networks and specialized surgical centers.

ClearFlow, Inc. manufactures specialized medical devices for cardiac surgery and cardiothoracic care. The company's primary product is PleuraFlow Active Chest Tube Clearance (ACT), a technology designed to prevent Retained Blood Syndrome and reduce postoperative complications in cardiac surgery patients. The PleuraFlow system actively clears blood and fluid from the thoracic cavity after surgery, demonstrating significant clinical benefits including 41% reduction in Retained Blood Syndrome, 17% reduction in postoperative atrial fibrillation, and 30% reduction in ICU length of stay when integrated into Enhanced Recovery After Surgery (ERAS) protocols. The company also offers ClearFix, a rigid sternal fixation system for stabilization and fixation of anterior chest wall fractures, including sternal fixation following sternotomy and sternal reconstructive procedures. ClearFlow's products are deployed in leading cardiac institutions and ICUs. The technology is supported by clinical evidence, including peer-reviewed publications demonstrating improved patient outcomes and resource utilization. The company serves cardiac surgeons, cardiothoracic surgical teams, and hospital ICU departments focused on reducing postoperative complications and improving recovery times in cardiac surgery populations.

Intramedical Imaging LLC manufactures and markets molecular imaging instruments for intraoperative cancer detection. The company has specialized in gamma probe technology since 1998, developing radioguided surgery solutions for sentinel lymph node mapping, radioactive seed localization, radioguided parathyroidectomy, and tumor localization. Their flagship product, the Node Seeker 2000 Gamma Probe, features the highest published sensitivity and resolution in the market—reportedly twice that of competing devices like the Neoprobe. The system includes a user-friendly touchscreen tablet control unit with real-time count display and battery monitoring. All probes are certified for Hydrogen Peroxide (H2O2) sterilization by Sterrad and Sterris, meeting OR infection control requirements. The Node Seeker system is designed for breast cancer, melanoma, and parathyroid surgery applications. The company serves surgical oncologists and OR staff in hospital and surgical center environments. Products are intraoperative molecular imaging devices for use during cancer surgery and endocrine procedures.

Medten USA Inc. is a B2B medical device parts and accessories distributor specializing in replacement cables, connectors, sensors, and consumable supplies for a broad range of clinical monitoring, anesthesia, respiratory, and surgical equipment. The company maintains an extensive inventory of aftermarket accessories compatible with equipment from major manufacturers including GE Healthcare, Philips, Masimo, Fisher & Paykel, Huntleigh, and others. Product categories include fetal monitoring cables and transducers, ECG and arrhythmia monitoring leadwires, anesthesia and respiratory system accessories (O2 sensors, flow sensors, humidifier components, ventilator adapters), patient monitoring cables (blood pressure, temperature, SpO2), tourniquet system components, electrosurgical unit (ESU) accessories, deep vein thrombosis (DVT) pump supplies, batteries and power supplies, endoscope system components, and miscellaneous interconnect cables. Medten serves hospitals, clinics, and medical equipment service organizations with replacement parts, repair supplies, and compatibility accessories. The company operates as a parts and accessories supplier rather than an OEM manufacturer, positioning itself as a source for cost-effective alternatives and hard-to-find legacy equipment components. Based on the extensive device compatibility database and catalog organization, Medten caters to facility biomedical departments, equipment service technicians, and procurement teams managing multi-vendor equipment portfolios.

Mizuho OSI is a surgical equipment manufacturer specializing in operating room tables and positioning systems for orthopedic, spinal, and trauma surgery. Founded over 40 years ago, the company pioneered the specialty surgery table market and continues to develop innovative intraoperative positioning solutions. Their product portfolio includes motorized surgical tables (ProAxis® for spinal surgery, Hana® for orthopedic procedures, and Trios® modular system), head positioning systems (Levó®), protective equipment (ProneView®), positioning accessories, pressure injury abatement products, and surgical consumables. Mizuho OSI serves hospitals, ambulatory surgery centers (ASCs), and specialty surgical facilities across the United States and internationally through distributors. The company emphasizes surgeon collaboration in product design, intraoperative positioning precision, and patient safety outcomes. Products are designed to provide superior patient positioning, improved surgical access, and the ability to make real-time adjustments during procedures. The organization offers comprehensive support including biomed and clinical training programs, in-service education, procedure setup resources, mobile applications, service contracts, technical support, and parts availability. California-based with US manufacturing and distribution capabilities.

True Digital Surgery (acquired by B. Braun) develops advanced 3D digital surgical microscope technology and visualization systems for the operating room. The company specializes in surgical imaging and visualization solutions, particularly for neurosurgery, spine surgery, and ENT procedures. For nearly two decades, True Digital Surgery has provided the technology powering trusted 3D surgical microscopes used globally. The Aesculap Aeos is their flagship 3D digital microscope platform designed for neurosurgery, spine, and ENT applications. The company's mission centers on building disruptive technologies that improve surgeon success and drive better patient outcomes. As a B. Braun subsidiary, True Digital Surgery benefits from the parent company's extensive regulatory credentials and global medical device distribution network. Their products support real-time surgical visualization and microscopic precision during complex procedures.

IntraOp Medical Corporation is a California-based manufacturer of electron therapy linear accelerators for cancer treatment. The company specializes in intraoperative radiotherapy (IORT) and non-invasive skin cancer treatment using compact, mobile electron beam devices. The Mobetron, IntraOp's flagship product introduced in 1997, is a self-shielded linear accelerator designed for deployment in operating rooms and outpatient settings. The Mobetron delivers precise electron beam therapy with applications in pancreatic cancer (PDAC), intraoperative radiotherapy, and non-melanoma skin cancer treatment. IntraOp is the first to offer ultra-high dose rate (UHDR) electron therapy approved for FLASH radiotherapy clinical trials, enabling preclinical investigation of FLASH on an established clinical platform. The company reports over 40 Mobetron units installed in leading cancer centers globally. IntraOp employs physicists, engineers, and designers in Silicon Valley to develop and support its radiation therapy systems. The Mobetron platform offers advantages including portability, dynamic pulse modulation, larger clinical volumes, excellent cosmesis for skin cancer cases, and reduced patient recovery times compared to surgical alternatives. Regulatory approvals for FLASH trials and clinical deployment in leading oncology centers establish the company's credibility in the radiation oncology market.

Nerbio Medical Software Platforms manufactures and delivers the iTOF®, the world's first and only FDA-cleared, wireless, app-controlled quantitative train-of-four (TOF) neuromuscular monitoring device. The iTOF connects to smartphones and tablets to provide real-time, quantitative neuromuscular assessments in perioperative settings without requiring bulky standalone equipment or significant capital investment. The platform integrates advanced AI assistance to help clinicians accurately guide neuromuscular blocking agent dosing and determine optimal post-operative recovery timing. Delivered as a Medical Device as a Service subscription model, iTOF operates at minimal daily cost (approximately $1/day) with full replacement warranty and no disposable costs. Clinical data demonstrates 10% improvement in operating room throughput, 15–30% reduction in neuromuscular blocking agent use, and significant reduction in post-operative residual blockade complications. The device is portable, battery-operated, hands-free, and compatible with both iOS and Android platforms. Nerbio is building a comprehensive platform of mobile, AI-powered monitoring solutions for perioperative and critical care environments.

Operating Room Innovations, Inc. is a San Diego-based medical device manufacturer specializing in innovative operating room solutions designed by surgeons and OR technicians for surgical safety, efficiency, and cost reduction. Founded by orthopedic surgeons and scrub technicians with over 80 years of combined OR experience, ORI develops cutting-edge products that enhance patient outcomes, improve workflow efficiency, and reduce operating room budgets. The company's core focus areas include surgical smoke evacuation, sterile instrument securing systems, surgical drapes, and infection control solutions. All products are engineered with the philosophy "Designed by Surgeons for Surgeons" to address real-world OR challenges and improve safety for both patients and healthcare staff.

Composite Manufacturing, Inc. (CMI) is an FDA-registered manufacturer and biomedical engineering company specializing in advanced carbon fiber and composite medical device design and production. For over 40 years, CMI has engineered custom composite solutions for neurological surgery, interventional neuroradiology, orthopedic procedures, urological interventions, and general surgical practices. The company manufactures radiolucent patient positioning systems, surgical tables, and imaging-compatible equipment featuring carbon fiber composites that are up to 5x stronger than aluminum at a fraction of the weight. CMI provides end-to-end capabilities including in-house design, tooling, prototyping, and manufacturing with vertical integration ensuring superior quality control, cost efficiency, and rapid market response. Their proprietary technologies enable complex geometries and high-performance solutions for demanding medical, surgical, and imaging applications.

Invenio Imaging, Inc. develops and commercializes the NIO Laser Imaging System, a stimulated Raman histology (SRH) platform that enables rapid, label-free tissue imaging for intraoperative pathology assessment. The NIO system delivers high-quality histological images in under 3 minutes without requiring tissue staining or sectioning, allowing on-site evaluation by surgical and pathology staff. The platform features the NIO Slide sample preparation module and integrates natively with existing hospital IT infrastructure via DICOM interfaces for digital image sharing and archiving. Invenio Imaging also offers NIO Glioma Reveal, a deep learning–based image analysis algorithm for identifying cancer infiltration in glioma surgery; this product has received CE Mark approval in the European Union and is available for research use only in the United States. The company serves multiple surgical specialties including neurosurgery, interventional pulmonology, urology, ENT, breast oncology, GI endoscopy, organ transplantation, and nephrology. The technology preserves tissue viability for downstream molecular and genetic analysis, enabling pathologists to conduct additional studies on the same specimen. The NIO platform has exceeded 2,000 installed systems globally and is supported by clinical evidence from leading academic medical centers including NYU Langone Health and University of Freiburg.